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Title: Adverse Drug Reactions Reported by Healthcare Professionals: Reaction Characteristics and Time to Reporting.
Austin Authors: Aung, Ar Kar;Tang, Mei Jie;Adler, Nikki R;de Menezes, Sara Lee;Goh, Michelle Sue Yen;Tee, Hui Wen;Trubiano, Jason ;Puy, Robert;Zubrinich, Celia Mary;Graudins, Linda Velta
Affiliation: Monash University Malaysia, Johor Bahru, Malaysia
Department of General Medicine, Alfred Health, Melbourne, Australia
Department of Infectious Diseases, Alfred Health, Melbourne, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Department of Dermatology, Alfred Health, Melbourne, Australia
Department of Infectious Diseases, Austin Health, Melbourne, Australia
Department of Medicine, University of Melbourne, Melbourne, Australia
Department of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, Australia
Pharmacy Department, Alfred Health, Melbourne, Australia
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia
Issue Date: 2018
Date: 2018-05-07
Publication information: Journal of clinical pharmacology 2018; 58(10): 1332-1339
Abstract: We describe adverse drug reaction (ADR) reporting characteristics and factors contributing to length of time to report by healthcare professionals. This is a retrospective study of voluntary reports to an Australian healthcare ADR Review Committee over a 2-year period (2015-2016). Descriptive and univariate models were used for outcomes, employing standardized ADR definitions. Hospital pharmacists reported 84.8% of the 555 ADRs: 70.3% were hospital onset reactions, and 71.7% were at least of moderate severity. Immunologically mediated reactions were most commonly reported (409, 73.7%). The median time to submit an ADR report was 3 (interquartile range 1-10) days. Longer median times to reporting were associated with multiple implicated agents and delayed hypersensitivity reactions, especially severe cutaneous adverse reactions. A total of 650 medications were implicated that involved multiple agents in 165/555 (29.7%) reports. Antimicrobials were the most commonly implicated agents. Immunologically mediated reactions were most commonly associated with antimicrobials and radiocontrast agents (P < .0001, odds ratio [OR] 3.6, 95%CI 2.4-5.5, and P = .04, OR 4.2, 95%CI 1.2-18.2, respectively). Opioids and psychoactive medications were more commonly implicated in nonimmunological reported ADRs (P = .0002, OR 3.9, 95%CI 1.9-7.9, and P < .0001, OR 11.4, 95%CI 4.6-27.8, respectively). Due to the predominant reporting of immunologically mediated reactions, a targeted education program is being planned to improve identification and accuracy of ADR reports, with the overall aim of improved management to ensure quality service provision and patient safety.
DOI: 10.1002/jcph.1148
Journal: Journal of clinical pharmacology
PubMed URL: 29733431
Type: Journal Article
Subjects: Adverse drug reactions
medication safety
Appears in Collections:Journal articles

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