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Title: The haemodynamic effects of bolus versus slower infusion of intravenous crystalloid in healthy volunteers.
Austin Authors: Ukor, Ida F;Hilton, Andrew K ;Bailey, Michael J;Bellomo, Rinaldo 
Affiliation: Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia
Department of Anaesthesia and Perioperative Medicine, Monash Medical Centre, Clayton, Melbourne, Victoria, Australia
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Alfred Centre, Prahran, Melbourne, Victoria, Australia
Issue Date: Oct-2017
Date: 2017-05-30
Publication information: Journal of Critical Care 2017; 41: 254-259
Abstract: This pilot study aimed to characterise the haemodynamic effect of 1L of IV normal saline (NS) administered as a rapid versus slow infusion on cardiac output (CO), heart rate (HR), systemic blood pressures, and carotid blood flow in six healthy volunteers. Six healthy male volunteers aged 18-65years were randomized to receive 1L NS given over 30min or 120min. On a subsequent study session the alternate fluid regimen was administered. Haemodynamic data was gathered using a non-invasive finger arterial pressure monitor (Nexfin®), echocardiography and carotid duplex sonography. Time to micturition and urine volume was also assessed. Compared to baseline, rapid infusion of 1L of saline over 30min produced a fall in Nexfin®-measured CO by 0.62L/min (p<0.001), whereas there was a marginal but significant increase during infusion of 1L NS over 120min of 0.02L/min (p<0.001). This effect was mirrored by changes in HR and blood pressure (BP) (p<0.001). There were no significant changes in carotid blood flow, time to micturition, or urine volume produced. Slower infusion of 1L NS in healthy male volunteers produced a greater increase in CO, HR and BP than rapid infusion.
DOI: 10.1016/j.jcrc.2017.05.036
ORCID: 0000-0002-1650-8939
Journal: Journal of Critical Care
PubMed URL: 28599199
Type: Journal Article
Subjects: Cardiac output
Fluid therapy
Healthy volunteers
Noninvasive monitoring
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