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Title: Albumin and depression in elderly stroke survivors: An observational cohort study.
Austin Authors: Pascoe, Michaela C;Skoog, Ingmar;Blomstrand, Christian;Linden, Thomas
Affiliation: Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Hunter Medical Research Institute, Newcastle, New Lambton Heights, NSW, Australia
Issue Date: 15-Dec-2015
Date: 2015-10-22
Publication information: Psychiatry research 2015; 230(2): 658-63
Abstract: Post-stroke depression affects approximately one third of stroke survivors. In non-stroke affected populations, depressive symptomatology is associated with hypoalbuminemia. This is also common among stroke survivors and associated with poor outcome and increased mortality. The role of stroke-associated hypoalbuminemia in post-stroke depression is not clear. We aimed to explore the relationship between serum albumin and post-stroke depression, as measured 20 months post-stroke. Observational cohort study of elderly Swedish patients drawn from the 'Gothenburg 70+ Stroke Study' (n=149) and assessed at 20 months after stroke onset. Serum albumin was drawn from venous blood and analysed with gas chromatography/mass spectrometry. Depressive symptomatology was assessed using the Montgomery-├ůsberg Depression Rating Scale (MADRS) and functional impairment was assessed using the Barthel Index. Analysis of covariance analysis showed that serum albumin levels were associated with depressive symptoms at 20 months after stroke. Multivariate analysis of covariance showed that disability scores at 3 days were associated with depressive symptoms at 20 months after stroke and after accounting for the age covariate. Stroke survivors were not clinically deficient in serum albumin. Low serum albumin appears to be associated with depressive symptoms in elderly individuals long term post-stroke.
DOI: 10.1016/j.psychres.2015.10.023
Journal: Psychiatry research
PubMed URL: 26520562
Type: Journal Article
Subjects: Depression
Old age
Risk Factors
Appears in Collections:Journal articles

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