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Title: Kruppel-Like Factor 15 Is Critical for the Development of Left Ventricular Hypertrophy.
Austin Authors: Patel, Sheila K ;Ramchand, Jay ;Crocitti, Vincenzo;Burrell, Louise M 
Affiliation: Medicine (University of Melbourne)
Issue Date: 27-Apr-2018
Date: 2018-04-27
Publication information: International Journal of Molecular Sciences 2018; 19(5): E1303
Abstract: Left ventricular hypertrophy (LVH) is an independent risk factor for adverse cardiovascular events and is often present in patients with hypertension. Treatment to reduce blood pressure and regress LVH is key to improving health outcomes, but currently available drugs have only modest cardioprotective effects. Improved understanding of the molecular mechanisms involved in the development of LVH may lead to new therapeutic targets in the future. There is now compelling evidence that the transcription factor Kruppel-like factor 15 (KLF15) is an important negative regulator of cardiac hypertrophy in both experimental models and in man. Studies have reported that loss or suppression of KLF15 contributes to LVH, through lack of inhibition of pro-hypertrophic transcription factors and stimulation of trophic and fibrotic signaling pathways. This review provides a summary of the experimental and human studies that have investigated the role of KLF15 in the development of cardiac hypertrophy. It also discusses our recent paper that described the contribution of genetic variants in KLF15 to the development of LVH and heart failure in high-risk patients.
DOI: 10.3390/ijms19051303
ORCID: 0000-0002-0626-1899
Journal: International Journal of Molecular Sciences
PubMed URL: 29702551
Type: Journal Article
Subjects: Kruppel-like factor 15
cardiac hypertrophy
genetics of left ventricular hypertrophy
heart failure
left ventricular hypertrophy
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