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Title: Examination of the relationship between disease activity and patient reported outcome measures in an Inflammatory Bowel Disease cohort.
Austin Authors: Jackson, Belinda D ;Con, Danny;Gorelik, Alexandra;Liew, Danny;Knowles, Simon;De Cruz, Peter
Affiliation: Gastroenterology and Hepatology
Department of Medicine, Austin Academic Centre, University of Melbourne, Melbourne, Australia
Melbourne EpiCentre, Royal Melbourne Hospital, Melbourne, Australia
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Department of Psychology, Swinburne University of Technology, Melbourne, Australia
Department of Psychiatry, University of Melbourne, Melbourne, Australia
Medicine (University of Melbourne)
Issue Date: 16-Apr-2018
Date: 2018-04-16
Publication information: Internal Medicine Journal 2018; 48(10): 1234-1241
Abstract: The extent to which disease activity impacts on patient reported outcomes (PROs) is unclear. The purpose of this study was to examine the relationship between disease activity and PROs. Adult IBD patients attending a tertiary clinic from May to June 2015 were included. Assessment of disease activity (SCCAI, HBI), IBD knowledge (CCKNOW), medication adherence (MMAS8), psychological distress (HADS), work productivity (WPAI) and quality of life (IBDQ) was performed to investigate any correlations between disease activity and PROs. 81 participants were included: 49% female; 57% Crohn's Disease (CD); 38% ulcerative colitis (UC); 5% IBD-unclassified; median age 34. At least mild levels of depression were present in 21/81 (26%) of patients; 37/81 (46%) expressed some level of anxiety. A moderate-to-strong correlation was found between disease activity and depression in UC (r=0.84, p=0.002) but not in CD (r=0.53, p=0.29). Disease activity correlated with: overall work impairment due to health (r=0.85, p=0.001), health related impairment while working (r=0.76, p=0.02), and percentage of activity impaired due to health (r=0.83, p=0.002) in UC only. Disease activity significantly affects mood and work productivity in patients with UC. Monitoring patients' ability to function and work, rather than minimizing disease activity alone, should become a routine part of IBD care.
DOI: 10.1111/imj.13937
ORCID: 0000-0002-9232-5480
Journal: Internal Medicine Journal
PubMed URL: 29663629
Type: Journal Article
Subjects: Crohn’s Disease
Inflammatory bowel disease
Patient Reported Outcomes
Ulcerative Colitis
Work Productivity
Appears in Collections:Journal articles

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