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Title: Systemic mastocytosis identified in two women developing fragility fractures during lactation.
Austin Authors: Zhu, J J;Mahendran, D;Lee, M H;Seah, J ;Fourlanos, S;Varadarajan, S;Ghasem-Zadeh, Ali ;MacIsaac, R J;Seeman, Ego 
Affiliation: Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, 41 Victoria Pde, Fitzroy, 3065, Victoria, Australia
Endocrine Centre of Excellence, Austin Health, Heidelberg, Victoria, Australia
Department of Endocrinology & Diabetes, The Northern Hospital, Epping, Australia
Department of Endocrinology & Diabetes, Royal Melbourne Hospital, Parkville, Australia
Department of Medicine, The University of Melbourne, Parkville, Australia
Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia
Issue Date: Jul-2018 2018-04-04
Publication information: Osteoporosis international 2018; 29(7): 1671-1674
Abstract: Two women presenting with fragility fractures during lactation had bone mineral density (BMD) reduced more greatly than usually associated with lactation. The first woman was 29 years old with a BMD T-score of - 3.2 SD at the spine and- 2.0 SD at the femoral neck. The second woman was 35 years old with a BMD T-score of - 4.5 SD at the spine and - 2.8 SD at the femoral neck. Both women had increased cortical porosity and reduced trabecular density. Investigation identified an elevated serum tryptase, and marrow biopsy confirmed the diagnosis of mastocytosis. Lactation causes bone loss, but the occurrence of fractures in the setting of severe deficits in BMD and microstructural deterioration signals the need to consider additional causes of bone loss.
DOI: 10.1007/s00198-018-4498-5
ORCID: 0000-0002-9692-048X
PubMed URL: 29619541
Type: Journal Article
Subjects: Bone loss
Appears in Collections:Journal articles

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