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Title: Biomaterials and Regenerative Medicine in Urology.
Austin Authors: Davis, Niall F;Cunnane, E M;Quinlan, M R;Mulvihill, J J;Lawrentschuk, Nathan;Bolton, Damien M ;Walsh, M T
Affiliation: Department of Urology, Austin Health, Heidelberg, Victoria, Australia
School of Engineering, Bernal Institute, Health Research Institute, University of Limerick, Limerick, Ireland
Issue Date: 2018 2018-01-17
Publication information: Advances in Experimental Medicine and Biology 2018; 1107: 189-198
Abstract: Autologous gastrointestinal tissue is the gold standard biomaterial for urinary tract reconstruction despite its long-term neuromechanical and metabolic complications. Regenerative biomaterials have been proposed as alternatives; however many are limited by a poor host derived regenerative response and deficient supportive elements for effective tissue regeneration in vivo. Urological biomaterials are sub-classified into xenogenic extracellular matrices (ECMs) or synthetic polymers. ECMs are decellularised, biocompatible, biodegradable biomaterials derived from animal organs. Synthetic polymers vary in chemical composition but may have the benefit of being reliably reproducible from a manufacturing perspective. Urological biomaterials can be 'seeded' with regenerative stem cells in vitro to create composite biomaterials for grafting in vivo. Mesenchymal stem cells are advantageous for regenerative purposes as they self-renew, have long-term viability and possess multilineage differentiation potential. Currently, tissue-engineered biomaterials are developing rapidly in regenerative urology with many important clinical milestones achieved. To truly translate from bench to bedside, regenerative biomaterials need to provide better clinical outcomes than current urological tissue replacement strategies.
DOI: 10.1007/5584_2017_139
ORCID: 0000-0001-8553-5618
Journal: Advances in Experimental Medicine and Biology
PubMed URL: 29340876
ISSN: 0065-2598
Type: Journal Article
Subjects: Biomaterials
Biomedical engineering
Regenerative medicine
Stem cells
Tissue engineering
Appears in Collections:Journal articles

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