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Title: Rapid development and recurrence of translocation renal cell carcinoma.
Austin Authors: Kinnear, Ned J;Wreghitt, Samuel ;Hennessey, Derek B;Liodakis, Peter 
Affiliation: Department of Urology, Austin Health, Heidelberg, Victoria, Australia
Department of Urology, Craigavon Area Hospital, Portadown, UK
Department of Surgery, University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 13-Jun-2017
Date: 2017-06-13
Publication information: BMJ Case Reports 2017; 2017; bcr-2017-219820
Abstract: Translocation renal cell carcinoma (RCC) is a rare aggressive malignancy in adults. A 40-year-old man presented with painless macroscopic haematuria. Initial investigations of renal ultrasound, CT scan, urine culture and urine cytology were normal. On rigid cystoscopy and pyelo-ureteroscopy, bleeding was seen from a normal-appearing right renal upper pole. An arteriovenous malformation was suspected, and laser cautery was performed. Left renal biopsy was performed due to proteinuria and suggested IgA nephropathy. The patient represented with haematuria and repeat imaging only 17 months after first presentation displayed a 9.8 cm right renal tumour with renal vein thrombus. An upper tract urothelial cancer was suspected, and the patient underwent right nephroureterectomy. Histopathology revealed translocation RCC, completely excised. Ten months postoperatively, metastasis was seen on surveillance imaging and subsequently confirmed on biopsy. The patient was referred for systemic therapy and remains alive 19 months postprocedure.
DOI: 10.1136/bcr-2017-219820
ORCID: 0000-0002-7833-2537
Journal: BMJ Case Reports
PubMed URL: 28611168
Type: Journal Article
Subjects: genetics
surgical oncology
urological cancer
urological surgery
Appears in Collections:Journal articles

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