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Title: SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.
Austin Authors: White, Katie D;Abe, Riichiro;Ardern-Jones, Michael;Beachkofsky, Thomas;Bouchard, Charles;Carleton, Bruce;Chodosh, James;Cibotti, Ricardo;Davis, Robert;Denny, Joshua C;Dodiuk-Gad, Roni P;Ergen, Elizabeth N;Goldman, Jennifer L;Holmes, James H;Hung, Shuen-Iu;Lacouture, Mario E;Lehloenya, Rannakoe J;Mallal, Simon;Manolio, Teri A;Micheletti, Robert G;Mitchell, Caroline M;Mockenhaupt, Maja;Ostrov, David A;Pavlos, Rebecca;Pirmohamed, Munir;Pope, Elena;Redwood, Alec;Rosenbach, Misha;Rosenblum, Michael D;Roujeau, Jean-Claude;Saavedra, Arturo P;Saeed, Hajirah N;Struewing, Jeffery P;Sueki, Hirohiko;Sukasem, Chonlaphat;Sung, Cynthia;Trubiano, Jason A ;Weintraub, Jessica;Wheatley, Lisa M;Williams, Kristina B;Worley, Brandon;Chung, Wen-Hung;Shear, Neil H;Phillips, Elizabeth J
Affiliation: Vanderbilt University Medical Center, Nashville, Tenn, USA
Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
University of Southampton, Southampton, United Kingdom
Wilford Hall Ambulatory Surgical Center, Lackland Air Force Base, San Antonio, Texas, USA
Loyola University Medical Center, Chicago, Ill, USA
University of British Columbia, Vancouver, British Columbia, Canada
B.C. Children's Hospital, British Columbia, Vancouver, British Columbia, Canada
Massachusetts Eye and Ear, Harvard Medical School, Boston, Mass, USA
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Md
University of Tennessee Health Sciences, Memphis, Tenn
Emek Medical Center, Technion-Institute of Technology, Afula, Israel
Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
University of Alabama at Birmingham, Birmingham, Ala
Children's Mercy Hospital Kansas City, Kansas City, Mo
Wake Forest Baptist Medical Center, Winston-Salem, NC
Wake Forest University School of Medicine, Winston-Salem, NC
National Yang-Ming University, Taipei, Taiwan
Memorial Sloan Kettering Cancer Center, New York, NY
University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa
Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
National Human Genome Research Institute, National Institutes of Health, Bethesda, Md
F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md
University of Pennsylvania, Philadelphia, Pa
Massachusetts General Hospital, Boston, Mass
Medical Center and Medical Faculty-University of Freiburg, Freiburg, Germany
University of Florida, Gainesville, Fla
University of Liverpool, Liverpool, United Kingdom
University of Toronto, Toronto, Ontario, Canada
University of California, San Francisco, Calif
University Paris-Est-Créteil, Créteil, France
Showa University School of Medicine, Tokyo, Japan
Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Duke-NUS Medical School, Singapore, Singapore; Health Sciences Authority, Singapore, Singapore
Austin Health, Heidelberg, Victoria, Australia
University of Melbourne, Melbourne, Victoria, Australia
US Food and Drug Administration, Silver Spring, Md
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md
University of Ottawa, Ottawa, Ontario, Canada
Chang Gung Memorial Hospital, Taipei, Taiwan
Hospital for Sick Children, Toronto, Ontario, Canada
Issue Date: 2018
Publication information: The journal of allergy and clinical immunology. In practice 2018; 6(1): 38-69
Abstract: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a life-threatening, immunologically mediated, and usually drug-induced disease with a high burden to individuals, their families, and society with an annual incidence of 1 to 5 per 1,000,000. To effect significant reduction in short- and long-term morbidity and mortality, and advance clinical care and research, coordination of multiple medical, surgical, behavioral, and basic scientific disciplines is required. On March 2, 2017, an investigator-driven meeting was held immediately before the American Academy of Dermatology Annual meeting for the central purpose of assembling, for the first time in the United States, clinicians and scientists from multiple disciplines involved in SJS/TEN clinical care and basic science research. As a product of this meeting, this article summarizes the current state of knowledge and expert opinion related to SJS/TEN covering a broad spectrum of topics including epidemiology and pharmacogenomic networks; clinical management and complications; special populations such as pediatrics, the elderly, and pregnant women; regulatory issues and the electronic health record; new agents that cause SJS/TEN; pharmacogenomics and immunopathogenesis; and the patient perspective. Goals include the maintenance of a durable and productive multidisciplinary network that will significantly further scientific progress and translation into prevention, early diagnosis, and management of SJS/TEN.
DOI: 10.1016/j.jaip.2017.11.023
PubMed URL: 29310768
Type: Journal Article
Subjects: Electronic health record
T cells
Toxic epidermal necrolysis
Appears in Collections:Journal articles

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