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Title: Childhood measles contributes to post-bronchodilator airflow obstruction in middle-aged adults: A cohort study.
Austin Authors: Perret, Jennifer L ;Matheson, Melanie C;Gurrin, Lyle C;Johns, David P;Burgess, John A;Thompson, Bruce R;Lowe, Adrian J;Markos, James;Morrison, Stephen S;McDonald, Christine F ;Wood-Baker, Richard;Svanes, Cecilie;Thomas, Paul S;Hopper, John L;Giles, Graham G;Abramson, Michael J;Walters, E Haydn;Dharmage, Shyamali C
Affiliation: Launceston General Hospital, Hobart, TAS, Australia
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, Victoria, Australia
Centre for International Health, University of Bergen, Bergen, Norway
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Occupational Medicine, Haukelaud University Hospital, Bergen, Norway
Institute for Breathing and Sleep, Heidelberg, Victoria, Australia
"Breathe Well" Centre of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, TAS, Australia
Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Department of Medicine, University of Queensland, Brisbane, QLD, Australia
Prince of Wales' Hospital Clinical School and School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
Department of Public Health, Seoul National University, Seoul, Republic of Korea
Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Issue Date: 20-Mar-2018 2018-03-20
Publication information: Respirology 2018; 23(8): 780-787
Abstract: Chronic obstructive pulmonary disease (COPD) has potential origins in childhood but an association between childhood measles and post-bronchodilator (BD) airflow obstruction (AO) has not yet been shown. We investigated whether childhood measles contributed to post-BD AO through interactions with asthma and/or smoking in a non-immunized middle-aged population. The population-based Tasmanian Longitudinal Health Study (TAHS) cohort born in 1961 (n = 8583) underwent spirometry in 1968 before immunization was introduced. A history of childhood measles infection was obtained from school medical records. During the fifth decade follow-up (n = 5729 responses), a subgroup underwent further lung function measurements (n = 1389). Relevant main associations and interactions by asthma and/or smoking on post-BD forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC; continuous variable) and AO (FEV1/FVC < lower limit of normal) were estimated by multiple regression. Sixty-nine percent (n = 950) had a history of childhood measles. Childhood measles augmented the combined adverse effect of current clinical asthma and smoking at least 10 pack-years on post-BD FEV1/FVC ratio in middle age (z-score: -0.70 (95% CI: -1.1 to -0.3) vs -1.36 (-1.6 to -1.1), three-way interaction: P = 0.009), especially for those with childhood-onset asthma. For never- and ever-smokers of <10 pack-years who had current asthma symptoms, compared with those without childhood measles, paradoxically, the odds for post-BD AO was not significant in the presence of childhood measles (OR: 12.0 (95% CI: 3.4-42) vs 2.17 (0.9-5.3)). Childhood measles infection appears to compound the associations between smoking, current asthma and post-BD AO. Differences between asthma subgroups provide further insight into the complex aetiology of obstructive lung diseases for middle-aged adults.
DOI: 10.1111/resp.13297
ORCID: 0000-0001-7034-0615
PubMed URL: 29560611
Type: Journal Article
Subjects: asthma-COPD overlap
childhood measles
current adult asthma
Appears in Collections:Journal articles

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