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Title: Emergence of multidrug resistance in locally-acquired human infections with Salmonella Typhimurium in Australia owing to a new clade harbouring blaCTX-M-9.
Austin Authors: Sparham, Sarah J;Kwong, Jason C ;Valcanis, Mary;Easton, Marion;Trott, Darren J;Seemann, Torsten;Stinear, Timothy P;Howden, Benjamin P 
Affiliation: Microbiological Diagnostic Unit Public Health Laboratory, Melbourne, Victoria, Australia
Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
Doherty Applied Microbial Genomics, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia
Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia
Department of Health and Human Services, Victorian Government, Australia
Australian Centre for Antimicrobial Resistance Ecology, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia
Melbourne Bioinformatics, The University of Melbourne, Carlton, Victoria, Australia
Issue Date: Jul-2017 2017
Publication information: International journal of antimicrobial agents 2017; 50(1): 101-105
Abstract: Antimicrobial resistance in non-typhoidal Salmonella is a critical problem globally, with the emergence of resistance to third-generation cephalosporins (3GCs) a particular concern. The aim of this study was to use whole-genome sequencing (WGS) to characterise recently identified human and non-human isolates of 3GC-resistant Salmonella enterica subsp. enterica serovar Typhimurium from Australia. The Illumina NextSeq sequencing platform was used to determine the genome sequences of 78 S. Typhimurium definitive type 44 isolated in Australia between 1992 and 2016, including 31 3GC-resistant isolates. Phylogenetic and bioinformatics analyses were subsequently performed using a number of in silico tools. We report the emergence of 3GC resistance in locally-acquired Australian S. Typhimurium for the first time. Phenotypically resistant isolates of human and animal origin were geographically restricted and were found by WGS all to be closely related and to carry blaCTX-M-9. Dairy cattle were the suspected source based on geographical clustering of animal isolates, which were predominantly bovine in origin. In conclusion, locally-acquired human cases of S. Typhimurium carrying blaCTX-M-9were identified that appear to be of bovine origin, raising concerns regarding the human impact of off-label use of ceftiofur in cattle.
DOI: 10.1016/j.ijantimicag.2017.02.014
PubMed URL: 28476613
Type: Journal Article
Subjects: Antimicrobial resistance
Extended-spectrum β-lactamase
One Health
Whole-genome sequencing
Appears in Collections:Journal articles

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