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Title: Does Fluid Type and Amount Affect Kidney Function in Critical Illness?
Austin Authors: Glassford, Neil J;Bellomo, Rinaldo 
Affiliation: Intensive Care Unit, Austin Health, Heidelberg, Victoria, Australia
Department of Epidemiology and Preventive Medicine, Monash University, Australian and New Zealand Intensive Care Research Centre, Melbourne, Victoria, Australia
School of Medicine, The University of Melbourne, VIC 3010, Australia
Issue Date: Apr-2018 2018-02-03
Publication information: Critical care clinics 2018; 34(2): 279-298
Abstract: Acute kidney injury (AKI) is common, although commonly used clinical diagnostic markers are imperfect. Intravenous fluid administration remains a cornerstone of therapy worldwide, but there is minimal evidence of efficacy for the use of fluid bolus therapy outside of specific circumstances, and emerging evidence associates fluid accumulation with worse renal outcomes and even increased mortality among critically ill patients. Artificial colloid solutions have been associated with harm, and chloride-rich solutions may adversely affect renal function. Large trials to provide guidance regarding the optimal fluid choices to prevent or ameliorate AKI, and promote renal recovery, are urgently required.
DOI: 10.1016/j.ccc.2017.12.006
ORCID: 0000-0002-1650-8939
PubMed URL: 29482907
Type: Journal Article
Subjects: Acute kidney injury
Balanced solution
Hydroxyethyl starch
Intravenous fluid therapy
Succinylated gelatin
Appears in Collections:Journal articles

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