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Title: A Novel Group-Fused Sparse Partial Correlation Method for Simultaneous Estimation of Functional Networks in Group Comparison Studies.
Austin Authors: Liang, Xiaoyun;Vaughan, David N;Connelly, Alan;Calamante, Fernando
Affiliation: The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Department of Neurology, Austin Health, Heidelberg, Victoria, Australia
The Florey Department of Neuroscience and Mental Health Medicine, University of Melbourne, Melbourne, Victoria, Australia
Department of Medicine, Austin Health and Northern Health, University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 29-Dec-2017
Date: 2017
Publication information: Brain topography 2018; 31(3): 364-379
Abstract: The conventional way to estimate functional networks is primarily based on Pearson correlation along with classic Fisher Z test. In general, networks are usually calculated at the individual-level and subsequently aggregated to obtain group-level networks. However, such estimated networks are inevitably affected by the inherent large inter-subject variability. A joint graphical model with Stability Selection (JGMSS) method was recently shown to effectively reduce inter-subject variability, mainly caused by confounding variations, by simultaneously estimating individual-level networks from a group. However, its benefits might be compromised when two groups are being compared, given that JGMSS is blinded to other groups when it is applied to estimate networks from a given group. We propose a novel method for robustly estimating networks from two groups by using group-fused multiple graphical-lasso combined with stability selection, named GMGLASS. Specifically, by simultaneously estimating similar within-group networks and between-group difference, it is possible to address inter-subject variability of estimated individual networks inherently related with existing methods such as Fisher Z test, and issues related to JGMSS ignoring between-group information in group comparisons. To evaluate the performance of GMGLASS in terms of a few key network metrics, as well as to compare with JGMSS and Fisher Z test, they are applied to both simulated and in vivo data. As a method aiming for group comparison studies, our study involves two groups for each case, i.e., normal control and patient groups; for in vivo data, we focus on a group of patients with right mesial temporal lobe epilepsy.
DOI: 10.1007/s10548-017-0615-6
ORCID: 0000-0002-1851-3408
Journal: Brain topography
PubMed URL: 29288387
PubMed URL:
Type: Journal Article
Subjects: Brain connectome
Functional connectivity
Graphical model
Inter-subject variability
Network metric
Sparse group penalty
Temporal lobe epilepsy
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