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Title: Does Statin Benefits Patients with Heart Failure Undergoing Percutaneous Coronary Intervention? Findings from the Melbourne Interventional Group Registry
Austin Authors: Chin, Ken Lee;Wolfe, Rory;Reid, Christopher M;Tonkin, Andrew;Hopper, Ingrid;Brennan, Angela;Andrianopoulos, Nick;Duffy, Stephen J;Clark, David;Ajani, Andrew;Liew, Danny
Affiliation: School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
Centre of Cardiovascular Research & Education (CCRE) in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Commercial Road, Melbourne, Victoria Australia
Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia
Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Issue Date: 18-Jan-2018 2018
Publication information: Cardiovascular drugs and therapy 2018; 32(1): 57-64
Abstract: The effectiveness of statins in improving clinical outcomes among patients with heart failure (HF) undergoing percutaneous coronary intervention (PCI) is unclear. We examined the association between use of statins and clinical outcomes in patients with HF included in the Melbourne Interventional Group registry. Patients were followed from 30 days to 1 year post-PCI for a primary composite outcome of all-cause mortality and hospitalisation for cardiovascular (CV) causes. Secondary outcomes included major adverse cardiac events (MACE, a composite of all-cause mortality, myocardial infarction and target vessel revascularisation) and hospitalisation for CV causes. Outcomes were compared between statin-treated and non-statin-treated patients (at 30 days post-PCI) using propensity scores to balance for risk factors. Among 991 patients included in the inverse probability-weighted Cox model, statin use had no significant effect on the primary composite outcome [adjusted hazard ratio (aHR), 1.03; 95% confidence interval (CI), 0.68 to 1.56; p = 0.89], nor MACE (aHR, 0.99; 95% CI, 0.54 to 1.84; p = 0.99) or hospitalisation for CV causes (HR, 1.13; 95% CI, 0.74 to 1.72; p = 0.57). Our results suggest that statin therapy may confer no significant benefits in patients with HF undergoing PCI. However, prospective randomised controlled trials are needed to provide more definitive answers.
DOI: 10.1007/s10557-018-6769-y
PubMed URL: 29349644
PubMed URL:
Type: Journal Article
Appears in Collections:Journal articles

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