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Title: Advance care planning in patients with incurable cancer: study protocol for a randomised controlled trial
Austin Authors: Johnson, Stephanie;Clayton, Josephine M;Butow, Phyllis N;Silvester, William;Detering, Karen M ;Hall, Jane;Kiely, Belinda E;Cebon, Jonathan S ;Clarke, Stephen;Bell, Melanie L;Stockler, Martin R;Beale, Phillip;Tattersall, Martin HN
Affiliation: Centre for Medical Psychology and Evidence-based Decision-making (CeMPED), School of Psychology, University of Sydney, Sydney, New South Wales, Australia
Department of Cancer Medicine, University of Sydney, Sydney, New South Wales, Australia
HammondCare Palliative and Supportive Care Service, Greenwich Hospital, Sydney, New South Wales, Australia
Kolling Institute of Medical Research, Northern Clinical School, University of Sydney, Sydney, New South Wales, Australia
Advance Care Planning Department, Austin Health, Heidelberg, Victoria, Australia
Centre for Health Economics Research and Evaluation, University of Technology, Sydney, New South Wales, Australia
National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, New South Wales, Australia
Ludwig Institute for Cancer Research, Melbourne, Victoria, Australia
Department of Medical Oncology, Royal North Shore Hospital Sydney, Sydney, New South Wales, Australia
Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA
Department of Medical Oncology, Sydney Local Health District (SLHD) and Royal Prince Alfred Hospital (RPA), Sydney, New South Wales, Australia
Issue Date: 1-Dec-2016 2016-12-01
Publication information: BMJ Open 2016; 6(12): e012387
Abstract: INTRODUCTION: There is limited evidence documenting the effectiveness of Advance Care Planning (ACP) in cancer care. The present randomised trial is designed to evaluate whether the administration of formal ACP improves compliance with patients' end-of-life (EOL) wishes and patient and family satisfaction with care. METHODS AND ANALYSIS: A randomised control trial in eight oncology centres across New South Wales and Victoria, Australia, is designed to assess the efficacy of a formal ACP intervention for patients with cancer. Patients with incurable cancer and an expected survival of 3-12 months, plus a nominated family member or friend will be randomised to receive either standard care or standard care plus a formal ACP intervention. The project sample size is 210 patient-family/friend dyads. The primary outcome measure is family/friend-reported: (1) discussion with the patient about their EOL wishes and (2) perception that the patient's EOL wishes were met. Secondary outcome measures include: documentation of and compliance with patient preferences for medical intervention at the EOL; the family/friend's perception of the quality of the patient's EOL care; the impact of death on surviving family; patient-family and patient-healthcare provider communication about EOL care; patient and family/friend satisfaction with care; quality of life of patient and family/friend subsequent to trial entry, the patient's strength of preferences for quality of life and length of life; the costs of care subsequent to trial entry and place of death. ETHICS AND DISSEMINATION: Ethical approval was received from the Sydney Local Health District (RPA Zone) Human Research Ethical Committee, Australia (Protocol number X13-0064). Study results will be submitted for publication in peer-reviewed journals and presented at national and international conferences. TRIAL REGISTRATION NUMBER: Pre-results; ACTRN12613001288718.
DOI: 10.1136/bmjopen-2016-012387
Journal: BMJ Open
PubMed URL:
Type: Journal Article
Subjects: Advance Directive
Advance care planning
End of Life
Randomised controlled trial
Appears in Collections:Journal articles

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