Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16995
Title: Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults
Austin Authors: Cooper, D James;McQuilten, Zoe K;Nichol, Alistair;Ady, Bridget;Aubron, Cécile;Bailey, Michael;Bellomo, Rinaldo ;Gantner, Dashiell;Irving, David O;Kaukonen, Kirsi-Maija;McArthur, Colin;Murray, Lynne;Pettilä, Ville;French, Craig;TRANSFUSE Investigators;Australian and New Zealand Intensive Care Society Clinical Trials Group
Affiliation: Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Department of Intensive Care, Alfred Hospital, Melbourne, Victoria, Australia
Department of Haematology, Monash Health, Melbourne, Victoria, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
The University of Melbourne, Melbourne, Victoria, Australia
Research and Development, Australian Red Cross Blood Service, Melbourne, Victoria, Australia
Irish Critical Care Clinical Trials Network, University College Dublin Clinical Research Centre at St. Vincent's University Hospital, Dublin
Département de Médecine Intensive Réanimation, Brest University Hospital, Brest, France
Department of Anesthesiology, University of Helsinki and Helsinki University Hospital, Helsinki
Division of Intensive Care, University of Helsinki and Helsinki University Hospital, Helsinki
Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki
Medical Research Institute of New Zealand and the Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand
Issue Date: Nov-2017
metadata.dc.date: 2017-09-27
Publication information: The New England Journal of Medicine 2017; 377: 1858-1867
Abstract: BACKGROUND: It is uncertain whether the duration of red-cell storage affects mortality after transfusion among critically ill adults. METHODS: In an international, multicenter, randomized, double-blind trial, we assigned critically ill adults to receive either the freshest available, compatible, allogeneic red cells (short-term storage group) or standard-issue (oldest available), compatible, allogeneic red cells (long-term storage group). The primary outcome was 90-day mortality. RESULTS: From November 2012 through December 2016, at 59 centers in five countries, 4994 patients underwent randomization and 4919 (98.5%) were included in the primary analysis. Among the 2457 patients in the short-term storage group, the mean storage duration was 11.8 days. Among the 2462 patients in the long-term storage group, the mean storage duration was 22.4 days. At 90 days, there were 610 deaths (24.8%) in the short-term storage group and 594 (24.1%) in the long-term storage group (absolute risk difference, 0.7 percentage points; 95% confidence interval [CI], -1.7 to 3.1; P=0.57). At 180 days, the absolute risk difference was 0.4 percentage points (95% CI, -2.1 to 3.0; P=0.75). Most of the prespecified secondary measures showed no significant between-group differences in outcome. CONCLUSIONS: The age of transfused red cells did not affect 90-day mortality among critically ill adults. (Funded by the Australian National Health and Medical Research Council and others; TRANSFUSE Australian and New Zealand Clinical Trials Registry number, ACTRN12612000453886 ; ClinicalTrials.gov number, NCT01638416 .).
URI: http://ahro.austin.org.au/austinjspui/handle/1/16995
DOI: 10.1056/NEJMoa1707572
ORCID: 0000-0002-1650-8939
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/28952891
Type: Journal Article
Subjects: Blood Preservation
Erythrocyte Transfusion/mortality
Critical Illness/therapy
Appears in Collections:Journal articles

Show full item record

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.