Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16895
Title: What, where and why: exploring fluorodeoxyglucose-PET's ability to localise and differentiate infection from cancer
Authors: Douglas, Abby
Lau, Eddie
Thursky, Karin A
Slavin, Monica A
Date of Publication: 15-Sep-2017
Citation: Current Opinion in Infectious Diseases 2017; online first: 15 September
Abstract: PURPOSE OF REVIEW: To review the utility of FDG-PET imaging in detecting the cause of fever and infection in patients with cancer. RECENT FINDINGS: FDG-PET has been shown to have high sensitivity and accuracy for causes of neutropenic fever, leading to higher diagnostic certainty in this group. Recent advances in pathogen-specific labelling in PET to identify Aspergillus spp. and Yersinia spp. infections in mice, as well as differentiating between Gram-positive, Gram-negative and mycobacterial infections are promising. SUMMARY: Patients with cancer are vulnerable to infection and fever, and the causes of these are frequently unclear using conventional diagnostic methods leading to high morbidity and mortality, length of stay and costs of care. FDG-PET/CT, with its unique complementary functional and anatomical information as well as its whole-body imaging capability, has demonstrated use in detecting occult infection in immunocompromised patients, including invasive fungal and occult bacterial infections, as well as defining extent of infection. By demonstrating disease resolution following treatment and allowing earlier cessation of therapy, FDG-PET acts as a key tool for antimicrobial and antifungal stewardship. Limitations include at times poor differentiation between infection, malignancy and sterile inflammation, however, exciting new technologies specific to infectious pathogens may help alleviate that issue. Further prospective randomised research is needed to explore these benefits in a nonbiased fashion.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16895
DOI: 10.1097/QCO.0000000000000405
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28922285
Type: Journal Article
Subject: Cancer
Computerised tomography
Diagnosis
Infection
Positron emission tomography
Appears in Collections:Journal articles

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