Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16889
Title: Bridging bio-nano science and cancer nanomedicine
Authors: Björnmal, Mattias
Thurecht, Kristofer J
Michael, Michael
Scott, Andrew M
Caruso, Frank
Date of Publication: 19-Sep-2017
Citation: ACS Nano 2017; online first: 19 September
Abstract: The interface of bio-nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core concepts of the field-e.g., the enhanced permeability and retention (EPR) effect, tumor targeting and accumulation, and even the purpose of "nano" in cancer medicine-are hotly debated. In parallel, considerable advances in neighboring fields are occurring rapidly, including the recent progress of "immuno-oncology" and the fundamental impact it is having on our understanding and the clinical treatment of the group of diseases collectively known as cancer. Herein, we (i) revisit how cancer is commonly treated in the clinic and how this relates to nanomedicine; (ii) examine the ongoing debate on the relevance of the EPR effect and tumor targeting; (iii) highlight ways to improve the next-generation of nanomedicines; and (iv) discuss the emerging concept of working with (and not against) biology. While discussing these controversies, challenges, emerging concepts, and opportunities, we explore new directions for the field of cancer nanomedicine.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16889
DOI: 10.1021/acsnano.7b04855
ORCID: 0000-0002-6656-295X
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28926225
Type: Journal Article
Subject: Antibodies
Comparative oncology
Heterogeneity
Metastasis
Nanoengineering
Nanomaterials
Nanoparticles
Tumor targeting
Appears in Collections:Journal articles

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