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Title: The relationship between sleep quality and brain amyloid burden
Austin Authors: Brown, Belinda M;Rainey-Smith, Stephanie R;Villemagne, Victor L ;Weinborn, Michael;Bucks, Romola S;Sohrabi, Hamid R;Laws, Simon M;Taddei, Kevin;Macaulay, S Lance;Ames, David;Fowler, Christopher J;Maruff, Paul;Masters, Colin L ;Rowe, Christopher C ;Martins, Ralph N;The AIBL Research Group
Affiliation: Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
School of Medical Sciences, Edith Cowan University, Joondalup, Western Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Nedlands, Western Australia
School of Psychology, University of Western Australia, Crawley, Western Australia
CSIRO Food and Nutrition, Parkville, Victoria, Australia
Department of Psychiatry, The University of Melbourne, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Florey Institute for Neurosciences and Mental Health, University of Melbourne, Victoria, Australia
Cogstate Ltd., Melbourne, Victoria, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Western Australia
Issue Date: 1-May-2016
Publication information: Sleep 2016; 39(5): 1063-1068
Abstract: STUDY OBJECTIVES: To evaluate the association between self-reported sleep quality and levels of brain β-amyloid (Aβ) burden, and to determine the effect of the apolipoprotein E (APOE) ε4 allele on any associations found. METHODS: This study is a cross-sectional analysis of 184 cognitively healthy men and women aged over 60 y. We measured sleep quality factors: specifically, sleep duration, latency (time taken to fall asleep), disturbances, efficiency, daytime dysfunction, and overall sleep quality, using the Pittsburgh Sleep Quality Index. All participants underwent Aβ positron emission tomography imaging for the quantification of brain Aβ burden and were APOE genotyped. Linear regression analyses were used to evaluate the relationship between sleep quality factors and brain Aβ burden, adjusting for age, body mass index, cardiovascular disease, and symptoms of depression, with APOE ε4 carriage entered as a moderator. RESULTS: Of the sleep factors, longer sleep latency was associated with higher levels of brain Aβ (B = 0.003 [standard error = 0.001], P = 0.02). APOE ε4 allele (carrier/noncarrier) did not moderate the relationship between sleep latency and brain Aβ burden. CONCLUSIONS: Our findings suggest a relationship between brain Aβ burden and sleep latency, independent of APOE ε4 genotype.
DOI: 10.5665/sleep.5756
ORCID: 0000-0003-3910-2453
PubMed URL:
Type: Journal Article
Subjects: Alzheimer disease
Apolipoprotein ε4 allele
Sleep latency
Appears in Collections:Journal articles

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