Please use this identifier to cite or link to this item:
Title: Neutrophils, G-CSF and their contribution to breast cancer metastasis
Austin Authors: Mouchemore, Kellie A;Anderson, Robin L ;Hamilton, John A
Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
La Trobe University School of Cancer Medicine, Bundoora, Victoria, Australia
Arthritis and Inflammation Research Centre, Department of Medicine, The University of Melbourne, Royal Melbourne Hospital, Parkville, Victoria, Australia
Issue Date: 21-Aug-2017 2017-08-21
Publication information: The FEBS Journal 2017; 285(4): 665-679
Abstract: Evidence is mounting for a role for neutrophils in breast cancer progression to metastasis. However, the role of G-CSF in neutrophil biology in a cancer setting remains to be defined. Herein we discuss the most recent clinical and experimental evidence for neutrophils and G-CSF in the promotion of metastasis, demonstrating a potential mechanistic link between them. Understanding this link is imperative both for the development of diagnostic tests and for therapies targeting neutrophils to improve the treatment of breast cancer patients with, or at risk of developing metastatic disease. Since a high neutrophil to lymphocyte ratio in patients predicts poor outcome, while mild neutropenia predicts an improved outcome, we urge caution in the use of G-CSF in neutrophil recovery following chemotherapy as there is increasing evidence in preclinical models that G-CSF can promote metastasis.
DOI: 10.1111/febs.14206
PubMed URL:
Type: Journal Article
Subjects: Breast cancer
Neutrophil extracellular traps
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Dec 7, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.