Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16809
Title: Neuropsychological function in patients with acute tetraplegia and sleep disordered breathing
Austin Authors: Schembri, Rachel;Spong, Jo;Graco, Marnie ;Berlowitz, David J ;COSAQ study team
Affiliation: Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia
La Trobe Rural Health School, College of Science, Health and Engineering, La Trobe University, Bendigo, Australia
COSAQ multinational collaborative research group
Issue Date: 1-Feb-2017
metadata.dc.date: 2016-10-20
Publication information: Sleep 2017; 40(2): zsw037
Abstract: STUDY OBJECTIVES: To investigate the relationship between apnoea severity and neuropsychological function in patients with acute onset tetraplegia and sleep disordered breathing. METHODS: Polysomnography and neuropsychological testing were performed on 104 participants (age M=45.60, SD=16.38; 10 female) across 11 international sites, two months post-injury (M=60.70 days, SD=39.48). Neuropsychological tests assessed attention, information processing, executive function, memory, learning, mood, and quality of life. RESULTS: More severe sleep apnoea was associated with poorer attention, information processing, and immediate recall. Deficits did not extend to memory. Higher pre-injury intelligence and being younger reduced the associations with sleep disordered breathing, however, these protective factors were insufficient to counter the damage to attention, immediate recall, and information processing associated with sleep disordered breathing. CONCLUSIONS: These data suggest that new spinal cord injury may function as a model of "acute sleep apnoea", and that more widespread sleep apnoea-related deficits, including memory, may only be seen with longer exposure to apnoea. These findings have important implications for functioning and skill acquisition during rehabilitation and, as such, highlight the importance of sleep health following tetraplegia.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16809
DOI: http://dx.doi.org/10.1093/sleep/zsw037
ORCID: 0000-0001-6048-0147
0000-0003-2543-8722
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27784405
Type: Journal Article
Subjects: Attention
Cognition
Information processing
Quadriplegia
Sleep apnoea
Spinal cord injury
Appears in Collections:Journal articles

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