Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16784
Title: Therapeutic CPAP level predicts upper airway collapsibility in patients with obstructive sleep apnea
Authors: Landry, Shane A
Joosten, Simon A
Eckert, Danny J
Jordan, Amy S
Sands, Scott A
White, David P
Malhotra, Atul 
Wellman, Andrew 
Hamilton, Garun S
Edwards, Bradley A
Date of Publication: 1-Jun-2017
Citation: Sleep 2017; 40(6): zsx056
Abstract: STUDY OBJECTIVES: Upper airway collapsibility is a key determinant of obstructive sleep apnea (OSA) which can influence the efficacy of certain non-continuous positive airway pressure (CPAP) treatments for OSA. However, there is no simple way to measure this variable clinically. The present study aimed to develop a clinically implementable tool to evaluate the collapsibility of a patient's upper airway. METHODS: Collapsibility, as characterized by the passive pharyngeal critical closing pressure (Pcrit), was measured in 46 patients with OSA. Associations were investigated between Pcrit and data extracted from patient history and routine polysomnography, including CPAP titration. RESULTS: Therapeutic CPAP level, demonstrated the strongest relationship to Pcrit (r2=0.51, p < .001) of all the variables investigated including apnea-hypopnea index, body mass index, sex, and age. Patients with a mildly collapsible upper airway (Pcrit ≤ -2 cmH2O) had a lower therapeutic CPAP level (6.2 ± 0.6 vs. 10.3 ± 0.4 cmH2O, p < .001) compared to patients with more severe collapsibility (Pcrit > -2 cmH2O). A therapeutic CPAP level ≤8.0 cmH2O was sensitive (89%) and specific (84%) for detecting a mildly collapsible upper airway. When applied to the independent validation data set (n = 74), this threshold maintained high specificity (91%) but reduced sensitivity (75%). CONCLUSIONS: Our data demonstrate that a patient's therapeutic CPAP requirement shares a strong predictive relationship with their Pcrit and may be used to accurately differentiate OSA patients with mild airway collapsibility from those with moderate-to-severe collapsibility. Although this relationship needs to be confirmed prospectively, our findings may provide clinicians with better understanding of an individual patient's OSA phenotype, which ultimately could assist in determining which patients are most likely to respond to non-CPAP therapies.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16784
DOI: 10.1093/sleep/zsx056
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28419320
Type: Journal Article
Subject: CPAP
Obstructive sleep apnea
Pcrit
Collapsibility
Phenotyping
Appears in Collections:Journal articles

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