Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16778
Title: Periodic Limb Movements in Tetraplegia
Austin Authors: Peters, Annemieke Emma Josina;van Silfhout, Lysanne;Graco, Marnie ;Schembri, Rachel;Thijssen, Dick;Berlowitz, David J 
Affiliation: Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Department of Physiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Issue Date: 2-May-2017
Publication information: Journal of Spinal Cord Medicine 2018; 41(3): 318-325
Abstract: OBJECTIVE: To establish the prevalence of Periodic Limb Movements during Sleep (PLMS) in patients with tetraplegia, controlling for obstructive sleep apnea. To explore whether demographic and injury characteristics affect PLMS. STUDY DESIGN: Retrospective cohorts. SETTING AND PARTICIPANTS: One hundred seventy-three participants with acute (<12 months) and 92 with chronic (>12 months) tetraplegia who underwent full overnight diagnostic sleep studies. INTERVENTIONS AND OUTCOME MEASURES: Two hundred sixty-two sleep study recordings were included. A randomly selected subgroup of 21 studies was assessed for PLM during wakefulness. Data were analysed according to the current American Academy of Sleep Medicine guidelines. RESULTS: Of the participants, 41.6% (43(15.7) years and 14.9% female) had a motor and sensory complete lesion. Sleep was poor with both OSA (87.8% with apnea hypopnoea index ≥ 5) and PLMS (58.4% with PLMS per hour PLMSI > 15) highly prevalent. There was no difference in the PLMSI between those with OSA (36.3(39.8)) or without (42.2(37.7), P = 0.42). PLMS were evident during REM and NREM sleep in all of the 153 patients with PLMSI > 15. All 21 participants in the subgroup of studies analysed for the PLM during quiet wakefulness, exhibited limb movements. None of the modelled variables (injury completeness, gender, OSA severity or time since injury) significantly predicted a PLMSI > 15 (P = 0.343). CONCLUSION: In conclusion, this study confirms the high prevalence of PLM in tetraplegia and the presence of leg movements in NREM and REM sleep along with wakefulness after controlling for OSA. No associations between the presence of PLMS and patient characteristics or injury specific aspects were found.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16778
DOI: 10.1080/10790268.2017.1320874
ORCID: 0000-0001-6048-0147
0000-0003-2543-8722
0000-0002-7397-977X
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/28464758
Type: Journal Article
Subjects: Cervical spinal Cord Injury
Obstructive sleep apnea
Periodic limb movements of sleep
Sleep
Tetraplegia
Type of Clinical Study or Trial: Cohort Study
Appears in Collections:Journal articles

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