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Title: A pilot study of peripheral blood BDCA-1 (CD1c) positive dendritic cells pulsed with NY-ESO-1 ISCOMATRIX™ adjuvant
Austin Authors: Davis, Ian D;Quirk, Juliet;Morris, Leone;Seddon, Lauren;Tai, Tsin Yee;Whitty, Genevieve;Cavicchiolo, Tina;Ebert, Lisa;Jackson, Heather;Browning, Judy;MacGregor, Duncan;Wittke, Frederick;Winkels, Gregor;Alex, Regina;Miloradovic, Lena;Maraskovsky, Eugene;Chen, Weisan;Cebon, Jonathan S 
Affiliation: Ludwig Institute for Cancer Research, Victoria, Australia
Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Monash University Eastern Health Clinical School, Box Hill, Victoria, Australia
Eastern Health, Victoria, Australia
Department of Anatomical Pathology, Austin Health, Heidelberg, Victoria, Australia
Miltenyi Biotec, Germany
CSL Limited, Melbourne, Victoria, Australia
School of Cancer Medicine, La Trobe University, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
Issue Date: Mar-2017 2017-02-10
Publication information: Immunotherapy 2017; 9(3): 249-259
Abstract: Pilot clinical trial of NY-ESO-1 (ESO) protein in ISCOMATRIX™ adjuvant pulsed onto peripheral blood dendritic cells (PBDC), to ascertain feasibility, evaluate toxicity and assess induction of ESO-specific immune responses. PATIENTS & METHODS: Eligible participants had resected cancers expressing ESO or LAGE-1 and were at high risk of relapse. PBDC were produced using CliniMACS®plus, with initial depletion of CD1c+ B cells followed by positive selection of CD1c+ PBDC. Patients received three intradermal vaccinations of ESO/IMX-pulsed PBDC at 4-week intervals. RESULTS: The process was feasible and safe. No vaccine-induced immune responses were detected. Assays of immunomodulatory cells did not correlate with outcomes. One patient had a long lasting complete remission. CONCLUSION: This method was feasible and safe but was minimally immunogenic.
DOI: 10.2217/imt-2016-0132
Journal: Immunotherapy
PubMed URL:
Type: Journal Article
Subjects: ISCOMATRIX™ adjuvant
Clinical trial
Dendritic cells
Type of Clinical Study or Trial: Clinical Trial
Appears in Collections:Journal articles

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