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Title: Elevated serum interleukin-5 levels in severe chronic obstructive pulmonary disease
Austin Authors: Perret, Jennifer L ;McDonald, Christine F ;Apostolopoulos, Vasso
Affiliation: Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
University of Melbourne, Parkville, Victoria, Australia
Immunology of Chronic Diseases Program, Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia
Issue Date: 1-Jun-2017
Publication information: Acta Biochimica et Biophysica Sinica 2017; 49(1): 560-563
Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disorder which is now ranked third as a leading cause of death [1]. Fixed airflow obstruction that is measured by spirometry following inhaled bronchodilator is essential to its diagnosis, and in its advanced stages, systemic manifestations such as inflammation and cachexia are also characteristic. In the lung, pathological features include increased number of airway neutrophils, a cytotoxic (Tc) predominant lymphocytic response associated with lymphoid follicles containing B and T cells, and increased proinflammatory cytokines including interleukin (IL)-6 and IL-8. Lung fibrosis and parenchymal destruction, also known as emphysema, can also be the feature in addition to obstruction of small airways. Some evidence...
DOI: 10.1093/abbs/gmx030
ORCID: 0000-0001-6481-3391
PubMed URL:
Type: Journal Article
Subjects: Cytokine
Chronic obstructive airway disease
Appears in Collections:Journal articles

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