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Title: N-acetylcysteine regimens for paracetamol overdose: time for a change?
Austin Authors: Wong, Anselm ;Graudins, Andis 
Affiliation: Austin Toxicology Service, Austin Health, Heidelberg, Victoria, Australia
Emergency Department, Austin Health, Heidelberg, Victoria, Australia
Monash Emergency Research Collaborative, School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia
Monash Toxicology Service, Program of Emergency Medicine, Monash Health, Melbourne, Victoria, Australia
Issue Date: Dec-2016 2016-05-18
Publication information: Emergency Medicine Australasia : EMA 2016; 28(6): 749-751
Abstract: Paracetamol overdose is one of the commonest pharmaceutical poisonings in the world. For nearly four decades, intravenous acetylcysteine regimens have been used to treat most patients successfully and prevent or mitigate hepatotoxicity. However, the rate of occurrence of adverse reactions to acetylcysteine is quite high, and there is a potential for these to be reduced. Recent studies show that distributing the loading-dose of acetylcysteine over the first few hours of treatment may decrease the incidence of adverse reactions. In addition, varying the duration of acetylcysteine administration may potentially benefit certain cohorts of poisoned patients, depending on their risk of developing hepatotoxicity.
DOI: 10.1111/1742-6723.12610
PubMed URL:
Type: Journal Article
Subjects: Acetaminophen
Appears in Collections:Journal articles

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