Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16721
Title: Breaking up sitting time after stroke (BUST-Stroke)
Austin Authors: Janssen, Heidi;Dunstan, David W;Bernhardt, Julie;Walker, Frederick R;Patterson, Amanda;Callister, Robin;Dunn, Ashlee;Spratt, Neil J;English, Coralie
Affiliation: Hunter Stroke Service, Hunter New England Local Health District, Newcastle, NSW, Australia
Centre for Research Excellence in Stroke Rehabilitation and Recovery, Hunter Medical Research Institute, Newcastle, NSW, Australia
School of Health Sciences, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
Priority Research Centre for Stroke and Brain Injury, University of Newcastle, Newcastle, NSW, Australia
Baker IDI Heart and Diabetes Institute, Melbourne Victoria, Australia
Centre for Research Excellence in Stroke Rehabilitation and Recovery, Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
University of Melbourne, Parkville, Victoria, Australia
School of Biomedical Science and Pharmacy, Faculty of Health, University of Newcastle, Newcastle, NSW, Australia
Priority Research Centre for Physical Activity and Nutrition, University of Newcastle, Newcastle, NSW, Australia
Department of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, NSW, Australia
Issue Date: Jun-2017
metadata.dc.date: 2016-10-28
Publication information: International Journal of Stroke 2017; 12(4): 425-429
Abstract: Rationale Prolonged sitting is associated with an increased risk of cardiovascular and all-cause mortality and morbidity. The metabolic and cardiovascular effects of breaking up sitting time in people with stroke are unknown. Aims and hypotheses To determine the (i) metabolic and cardiovascular effects and (ii) safety and feasibility of an experimental protocol to break up uninterrupted sitting in people with stroke. We hypothesize that activity breaks will attenuate the effects of uninterrupted sitting on glucose and insulin metabolism, blood pressure, lipid profiles, and plasma fibrinogen and that it will be both safe and feasible. Sample size estimate Based on previous estimates of population variability (SD 1% glucose and 30% insulin), 19 paired observations (i.e. participants) will achieve a power of 0.9 to detect a difference of 0.8% in glucose and 24% in insulin area under the curve (two-tailed testing, α = 0.05). Methods and design People with stroke will complete three experimental conditions one week apart in randomized order: (a) uninterrupted sitting, (b) prolonged sitting with intermittent walking, and (c) prolonged sitting with intermittent standing exercises. Serial blood samples will be collected and blood pressure measured at 30 min intervals for 8 h. Study outcomes Primary outcome will be postprandial glucose and insulin responses. Secondary outcomes will include fibrinogen concentrations, blood pressure, and adverse events and protocol feasibility. Discussion This is the first important step in determining the cardiovascular effects of breaking up sitting time after stroke. Findings will guide future studies testing behavioral strategies to reduce sitting time for the purpose of lowering recurrent stroke risk.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16721
DOI: 10.1177/1747493016676616
ORCID: 0000-0003-2543-8722
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27794137
Type: Journal Article
Subjects: Sitting
Cardiovascular disease
Physical activity
Rehabilitation
Stroke
Stroke risk
Appears in Collections:Journal articles

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