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Title: Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes
Austin Authors: Tan, Rachel H;Kril, Jillian J;Yang, Yue;Tom, Nicole;Hodges, John R;Villemagne, Victor L ;Rowe, Christopher C ;Leyton, Cristian E;Kwok, John BJ;Ittner, Lars M;Halliday, Glenda M
Affiliation: Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia
Neuroscience Research Australia, Sydney, New South Wales, Australia
Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
Department of Molecular Imaging and Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Faculty of Health Sciences, Discipline Speech Pathology, The University of Sydney, Sydney, New South Wales, Australia
Issue Date: 29-May-2017 2017-05-29
Publication information: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring 2017; 9: 10-20
Abstract: INTRODUCTION: The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ in pathologically confirmed FTD syndromes. METHODS: Aβ was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of 11C-Pittsburgh compound B (PiB)-positron emission tomography imaging was assessed in a subset of FTD cases (n = 15). RESULTS: Aβ was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aβ with PiB standard uptake value ratio scaled to the white matter. DISCUSSION: The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.
DOI: 10.1016/j.dadm.2017.05.005
PubMed URL:
Type: Journal Article
Subjects: Frontotemporal dementia syndromes
Alzheimer's disease
Amyloid β
C-Pittsburgh compound B
Appears in Collections:Journal articles

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