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Title: Integrating smoking cessation into routine care in hospitals—a randomized controlled trial
Austin Authors: Thomas, D;Abramson, Michael J;Bonevski, B;Taylor, Simone E ;Poole, SG;Paul, E;Weeks, GR;Dooley, MJ;George, J
Affiliation: Centre for Medicine Use and Safety, Monash University, Melbourne, Victoria, Australia
Department of Epidemiology and Preventive Medicine, Monash University, The Alfred, Melbourne, Victoria, Australia
School of Medicine and Public Health, University of Newcastle, Callaghan, New South Wales, Australia
Pharmacy Department, Austin Health, Heidelberg, Victoria, Australia
Pharmacy Department, Alfred Health, Melbourne, Victoria, Australia
Clinical Haematology Department, The Alfred, Melbourne, Victoria, Australia
Pharmacy Department, Barwon Health, Geelong, Victoria, Australia
Issue Date: Apr-2016 2016-01-13
Publication information: Addiction 2016; 111(4): 714-723
Abstract: AIMS: To evaluate the effectiveness of a pharmacist-led multi-component smoking cessation programme (GIVE UP FOR GOOD) compared with usual care in hospitalized smokers. DESIGN: Randomized, assessor-blinded, parallel-group trial. SETTING: Three tertiary public hospitals in Australia. PARTICIPANTS: A total of 600 adult in-patient smokers [mean ± standard deviation (SD), age 51 ± 14 years; 64% male] available for 12 months follow-up. INTERVENTIONS: Multi-component hospital pharmacist-led behavioural counselling and/or pharmacotherapy provided during hospital stay, on discharge and 1 month post-discharge, with further support involving community health professionals (n = 300). Usual care comprised routine care provided by hospitals (n = 300). MEASUREMENTS: Two primary end-points were tested using intention-to-treat analysis: carbon monoxide (CO)-validated 1-month sustained abstinence at 6-month follow-up and verified 6-month sustained abstinence at 12-month follow-up. Smoking status and pharmacotherapy usage were assessed at baseline, discharge, 1, 6 and 12 months. FINDINGS: Sustained abstinence rates for intervention and control groups were not significantly different at both 6 months [11.6% (34 of 294) versus 12.6% (37 of 294); odds ratio (OR) = 0.91, 95% confidence interval (CI) = 0.55-1.50] and 12 months [11.6% (34 of 292) versus 11.2% (33 of 294); OR = 1.04, 95% CI = 0.63-1.73]. Secondary end-points, self-reported continuous abstinence at 6 and 12 months, also agreed with the primary end-points. Use of pharmacotherapy was higher in the intervention group, both during hospital stay [52.3% (157 of 300) versus 42.7% (128 of 300); P = 0.016] and after discharge [59.6% (174 of 292) versus 43.5% (128 of 294); P < 0.001]. CONCLUSIONS: A pharmacist-led multi-component smoking cessation intervention provided during hospital stay did not improve sustained abstinence rates at either 6 or 12 months compared with routine hospital care.
DOI: 10.1111/add.13239
Journal: Addiction
PubMed URL:
Type: Journal Article
Subjects: Hospitals
Randomized controlled trial
Smoking cessation
Type of Clinical Study or Trial: Randomized Controlled Clinical Trial/Controlled Clinical Trial
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