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Title: Modern intermittent haemodialysis (IHD) is an effective method of removing salicylate in chronic topical salicylate toxicity
Austin Authors: Wong, Anselm ;Mac, Kathy;Aneman, Anders;Wong, Jeffrey;Chan, Betty S
Affiliation: Victorian Poisons Information Centre and Austin Toxicology Service, Austin Health, Heidelberg, Victoria, Australia
School of Clinical Sciences, Department of Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia
Renal unit, Liverpool Hospital, Sydney, NSW, Australia
Intensive Care Unit, Liverpool Hospital, Sydney, NSW, Australia
Clinical Toxicology Unit, Prince of Wales Hospital, Sydney, NSW, Australia
Issue Date: Mar-2016
Publication information: Journal of Medical Toxicology 2016; 12(1): 130-133
Abstract: INTRODUCTION: There are limited data on modern intermittent hemodialysis (IHD) efficacy on salicylate elimination from topical poisoning. CASE REPORT: A 54-year-old male sought treatment for dyspnea but was then diagnosed with salicylate toxicity from topical application of Dencorub Extra Strength Heat Gel® for 1 week. Each tube contained 100 g with 26 % methylsalicylate (26 g). Laboratory workup was remarkable for an elevated anion gap of 30 and salicylate concentration of 78.7 mg/dL [5.7 mmol/L (N < 0.4 mmol/L)]. Treatment with urinary alkalinization was followed by hemodialysis for 5 h. Extraction ratios were 0.44 with clearance rates of 78.5 mL/min. Salicylate concentrations fell rapidly following initiation of hemodialysis with no rebound observed. DISCUSSION: Modern high flux IHD is an effective method of removing salicylates in the treatment of chronic topical poisoning.
DOI: 10.1007/s13181-015-0502-z
PubMed URL:
Type: Journal Article
Subjects: Hemodialysis
Appears in Collections:Journal articles

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