Austin Health

Title
Drug-specific upregulation of CD137 on CD8+ T cells aids in the diagnosis of multiple antibiotic toxic epidermal necrolysis
Publication Date
2017-05
Author(s)
Trubiano, Jason
Redwood, Alec
Strautins, Kaija
Pavlos, Rebecca
Woolnough, Emily
Chang, Christina C
Phillips, Elizabeth
Type of document
Journal Article
OrcId
0000-0002-5111-6367
DOI
10.1016/j.jaip.2016.09.043
Abstract
There are major challenges defining drug causality in cases of severe cutaneous adverse reactions (SCAR) involving multiple antibiotics. We describe a case of toxic epidermal necrolysis (TEN) occurring in the setting of multiple antibiotics and the use of IFN-γ enzyme-linked immunospot assay and flow cytometry to clarify causality.
Link
Citation
The Journal of Allergy and Clinical Immunology: In Practice 2017; 5(3): 823-826
Jornal Title
The Journal of Allergy and Clinical Immunology: In Practice

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