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Title: Drug-specific upregulation of CD137 on CD8+ T cells aids in the diagnosis of multiple antibiotic toxic epidermal necrolysis
Austin Authors: Trubiano, Jason A ;Redwood, Alec;Strautins, Kaija;Pavlos, Rebecca;Woolnough, Emily;Chang, Christina C;Phillips, Elizabeth
Affiliation: Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Department of Infectious Diseases, Peter MacCallum Cancer Centre, Parkville, Victoria, Australia
Department of Infectious Diseases, Alfred Health, Melbourne, Victoria, Australia
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Department of Pharmacology, Oates Institute for Experimental Therapeutics, Vanderbilt University Medical School, Nashville, Tennessee, USA
Issue Date: May-2017 2016-11-22
Publication information: The Journal of Allergy and Clinical Immunology: In Practice 2017; 5(3): 823-826
Abstract: There are major challenges defining drug causality in cases of severe cutaneous adverse reactions (SCAR) involving multiple antibiotics. We describe a case of toxic epidermal necrolysis (TEN) occurring in the setting of multiple antibiotics and the use of IFN-γ enzyme-linked immunospot assay and flow cytometry to clarify causality.
DOI: 10.1016/j.jaip.2016.09.043
ORCID: 0000-0002-5111-6367
PubMed URL:
Type: Journal Article
Type of Clinical Study or Trial: Case Series and Case Reports
Appears in Collections:Journal articles

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