Please use this identifier to cite or link to this item:
Title: An overview of the innate and adaptive immune system in inflammatory bowel disease
Austin Authors: Choy, Matthew C ;Visvanathan, Kumar;De Cruz, Peter
Affiliation: Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia
Department of Gastroenterology, St Vincent's Hospital, Melbourne, Australia
Department of Medicine, Austin Academic Centre, University of Melbourne, Melbourne, Australia
Department of Medicine, Eastern Hill Academic Centre, University of Melbourne, Melbourne, Australia
Issue Date: Jan-2017
Publication information: Inflammatory Bowel Diseases 2017; 23(1): 2-13
Abstract: Inflammatory bowel diseases (IBDs) are thought to develop as a result of complex interactions between host genetics, the immune system and the environment including the gut microbiome. Although an improved knowledge of the immunopathogenesis of IBDs has led to great advances in therapy such as the highly effective anti-tumor necrosis factor class of medications, a significant proportion of patients with Crohn's disease and ulcerative colitis do not respond to anti-tumor necrosis factor antibodies. Further understanding of the different immune pathways involved in the genesis of chronic intestinal inflammation is required to help find effective treatments for IBDs. In this review, the role of the mucosal innate and adaptive immune system in IBD is summarized, highlighting new areas of discovery which may hold the key to identifying novel predictive or prognostic biomarkers and new avenues of therapeutic discovery.
DOI: 10.1097/MIB.0000000000000955
Journal: Inflammatory Bowel Diseases
PubMed URL:
Type: Journal Article
Subjects: Adaptive Immunity
Colitis, Ulcerative
Crohn Disease
Immunity, Innate
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Jan 30, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.