Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16455
Title: Synaptic Zn2+ and febrile seizure susceptibility
Austin Authors: Reid, Christopher A;Hildebrand, Michael S ;Mullen, Saul A ;Hildebrand, Joanne M;Berkovic, Samuel F ;Petrou, Steven
Affiliation: The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Epilepsy Research Centre, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
Cell Signalling and Cell Death Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia
Issue Date: Jan-2017
metadata.dc.date: 2016-10-23
Publication information: British Journal of Pharmacology 2017; 174(2): 119-125
Abstract: Zn2+ , the second most prevalent trace element in the body, is essential for supporting a wide range of biological functions. While the majority of Zn2+ in the brain is protein-bound, a significant proportion of free Zn2+ is found co-localized with glutamate in synaptic vesicles and is released in an activity-dependent manner. Clinical studies have shown Zn2+ levels are significantly lower in blood and cerebrospinal fluid of children that suffer febrile seizures. Likewise, investigations in multiple animal models demonstrate that low levels of brain Zn2+ increase seizure susceptibility. Recent work provides human genetic evidence that disruption of brain Zn2+ homeostasis at the level of the synapse is associated with increased seizure susceptibility. In this review we will explore the clinical, functional and genetic data supporting the view that low synaptic Zn2+ increases cellular excitability and febrile seizure susceptibility. Finally, the review will focus on the potential of therapeutic Zn2+ supplementation for at risk patients.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16455
DOI: 10.1111/bph.13658
ORCID: 0000-0003-4580-841X
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27771943
Type: Journal Article
Subjects: Zn2+
Diet
Febrile seizures
Fever
Inflammation
Synaptic
Zinc
Appears in Collections:Journal articles

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