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Title: Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease
Austin Authors: Kerestes, Rebecca;Phal, Pramit M;Steward, Chris;Moffat, Bradford A;Salinas, Simon;Cox, Kay L;Ellis, Kathryn A;Cyarto, Elizabeth V;Ames, David;Martins, Ralph N;Masters, Colin L ;Rowe, Christopher C ;Sharman, Matthew J;Salvado, Olivier;Szoeke, Cassandra;Lai, Michelle;Lautenschlager, Nicola T;Desmond, Patricia M
Affiliation: Department of Radiology, The Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia
National Ageing Research Institute, University of Melbourne, Parkville, Victoria, Australia
School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
School of Health Sciences, University of Tasmania, Hobart, Tasmania, Australia
Commonwealth Scientific Industrial Research Organization Preventative Health National Research Flagship, Australian e-Health Research Centre, Brisbane, Queensland, Australia
North Western Mental Health, Melbourne Health, Melbourne, Victoria, Australia
Issue Date: Oct-2015 2015-11-09
Publication information: BJPsych Open 2015; 1(2): 139-148
Abstract: BACKGROUND: Recent evidence suggests that exercise plays a role in cognition and that the posterior cingulate cortex (PCC) can be divided into dorsal and ventral subregions based on distinct connectivity patterns. AIMS: To examine the effect of physical activity and division of the PCC on brain functional connectivity measures in subjective memory complainers (SMC) carrying the epsilon 4 allele of apolipoprotein E (APOE ε4) allele. METHOD: Participants were 22 SMC carrying the APOE ε4 allele (ε4+; mean age 72.18 years) and 58 SMC non-carriers (ε4-; mean age 72.79 years). Connectivity of four dorsal and ventral seeds was examined. Relationships between PCC connectivity and physical activity measures were explored. RESULTS: ε4+ individuals showed increased connectivity between the dorsal PCC and dorsolateral prefrontal cortex, and the ventral PCC and supplementary motor area (SMA). Greater levels of physical activity correlated with the magnitude of ventral PCC-SMA connectivity. CONCLUSIONS: The results provide the first evidence that ε4+ individuals at increased risk of cognitive decline show distinct alterations in dorsal and ventral PCC functional connectivity.
DOI: 10.1192/bjpo.bp.115.001339
ORCID: 0000-0003-3910-2453
PubMed URL:
Type: Journal Article
Subjects: Alzheimer disease
Gyrus Cinguli
Appears in Collections:Journal articles

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