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Title: | Judging quality of current septic shock definitions and criteria | Austin Authors: | Shankar-Hari, Manu;Bertolini, Guido;Brunkhorst, Frank M;Bellomo, Rinaldo ;Annane, Djillali;Deutschman, Clifford S;Singer, Mervyn | Affiliation: | Department of Intensive Care Medicine, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK Division of Asthma, Allergy and Lung Biology, King's College London, London UK Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Villa Camozzi, Ranica (Bergamo), Italy Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena, Germany Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia Department of Medicine, Austin Health, Heidelberg, Victoria, Australia Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, Garches, France Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park, NY, USA Feinstein Institute for Medical Research, Manhasset, NY, USA Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK |
Issue Date: | 25-Dec-2015 | Date: | 2015-12-25 | Publication information: | Critical Care 2015; 19: 445 | Abstract: | Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using either hypotension or a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that concurrent presence of cardiovascular dysfunction and perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/16363 | DOI: | 10.1186/s13054-015-1164-6 | Journal: | Critical Care | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/26702879 | Type: | Journal Article | Subjects: | International Classification of Diseases Shock, Septic Terminology as Topic |
Appears in Collections: | Journal articles |
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