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Title: Judging quality of current septic shock definitions and criteria
Austin Authors: Shankar-Hari, Manu;Bertolini, Guido;Brunkhorst, Frank M;Bellomo, Rinaldo ;Annane, Djillali;Deutschman, Clifford S;Singer, Mervyn
Affiliation: Department of Intensive Care Medicine, St Thomas' Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK
Division of Asthma, Allergy and Lung Biology, King's College London, London UK
Laboratory of Clinical Epidemiology and GiViTI Coordinating Centre, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Villa Camozzi, Ranica (Bergamo), Italy
Paul-Martini-Research Group for Clinical Sepsis Research, Center for Clinical Studies, Jena University Hospital, Salvador-Allende-Platz 29, Jena, Germany
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
Department of Intensive Care Medicine, Hôpital Raymond Poincaré (AP-HP), Laboratory of Cell Death, Inflammation & Infection, UMR1173 University of Versailles SQY & INSERM, Garches, France
Departments of Pediatrics and Molecular Medicine, Hofstra-North Shore-Long Island Jewish-Hofstra School of Medicine, New Hyde Park, NY, USA
Feinstein Institute for Medical Research, Manhasset, NY, USA
Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
Issue Date: 25-Dec-2015 2015-12-25
Publication information: Critical Care 2015; 19: 445
Abstract: Septic shock definitions are being revisited. We assess the feasibility, reliability, and validity characteristics of the current definitions and criteria of septic shock. Septic shock is conceptualised as cardiovascular dysfunction, tissue perfusion and cellular abnormalities caused by infection. Currently, for feasibility, septic shock is identified at the bedside by using either hypotension or a proxy for tissue perfusion/cellular abnormalities (e.g., hyperlactatemia). We propose that concurrent presence of cardiovascular dysfunction and perfusion/cellular abnormalities could improve validity of septic shock diagnosis, as we are more likely to identify a patient population with all elements of the illness concept. This epidemiological refinement should not affect clinical care and may aid study design to identify illness-specific biomarkers and interventions.
DOI: 10.1186/s13054-015-1164-6
PubMed URL:
Type: Journal Article
Subjects: International Classification of Diseases
Shock, Septic
Terminology as Topic
Appears in Collections:Journal articles

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