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Title: Immunotherapy for malignant mesothelioma: reality check
Austin Authors: Thapa, Bibhusal ;Watkins, D Neil;John, Thomas 
Affiliation: Medicine (University of Melbourne)
Cancer Imuunobiology Lab, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
The Kinghorn Cancer Center, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Medical Oncology
School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Wellness and Research Centre
Issue Date: 6-Oct-2016
Date: 2016-10-06
Publication information: Expert Review of Anticancer Therapy 2016; online first: 6 October
Abstract: Initial data of immune based therapy showed promise for improving malignant mesothelioma (MM) treatment. However, the results of such treatments have neither been predictable nor consistent and recent clinical studies of immune checkpoint inhibitors in MM have dampened initial enthusiasm. Areas covered: We comprehensively discuss the basis, modalities and updated results of immunotherapy in MM. An online search was conducted for relevant literature and abstracts of recent meetings. Expert commentary: Although initial studies have demonstrated proof of principle that manipulating the immune checkpoint axis holds promise in MM, results of some recent large studies using checkpoint inhibitors have been disappointing. This is not surprising given the low mutational load in MM and suggests that single agent immunotherapy has limited benefit in this disease. We believe that in order to demonstrate durable survival benefits, they will need to be used in combination approaches with other immunotherapies, vaccines or chemotherapy.
DOI: 10.1080/14737140.2016.1241149
Journal: Expert Review of Anticancer Therapy
PubMed URL:
Type: Journal Article
Subjects: Mesothelioma
Check point inhibition
Therapeutic vaccines
Appears in Collections:Journal articles

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