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Title: Impact of door-to-balloon time on long-term mortality in high- and low-risk patients with ST-elevation myocardial infarction
Austin Authors: Yudi, Matias B ;Ramchand, Jay ;Farouque, Omar ;Andrianopoulos, Nick;Chan, William;Duffy, Stephen J;Lefkovits, Jeffrey;Brennan, Angela L;Spencer, Ryan J;Fernando, Dharsh;Hiew, Chin;Freeman, Melanie;Reid, Christopher M;Ajani, Andrew E;Clark, David J ;Melbourne Interventional Group
Affiliation: Department of Cardiology, Austin Health, Heidelberg, Victoria, Australia
The University of Melbourne, Melbourne, Victoria, Australia
Centre of Cardiovascular Research and Education in Therapeutics (CCRE), Monash University, Melbourne, Victoria, Australia
Department of Cardiology, Alfred Hospital, Melbourne, Victoria, Australia
Department of Cardiology, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Cardiology, Geelong Hospital, Geelong, Victoria, Australia
Department of Cardiology, Box Hill Hospital, Box Hill, Victoria, Australia
School of Public Health, Curtin University, Perth, Western Australia, Australia
Issue Date: 1-Dec-2016
Date: 2016-09-05
Publication information: International Journal of Cardiology 2016; 224: 72-78
Abstract: BACKGROUND: Door-to-balloon time (DTBT) less than 90min remains the benchmark of timely reperfusion in ST-elevation myocardial infarction (STEMI). The relative long-term benefit of timely reperfusion in STEMI patients with differing risk profiles is less certain. Thus, we aimed to assess the impact of DTBT on long-term mortality in high- and low-risk STEMI patients. METHOD: We analysed baseline clinical and procedural characteristics of 2539 consecutive STEMI patients who underwent primary percutaneous coronary intervention (PCI) from the Melbourne Interventional Group registry from 2004 to 2012. Patients were classified high risk (HR-STEMI) if they presented with cardiogenic shock, out-of-hospital cardiac arrest (OHCA) or Killip class ≥2; or low-risk (LR-STEMI) if there were no high-risk features. We then stratified high- and low-risk patients by DTBT (≤90min vs. >90min) and assessed long-term mortality. RESULT: Of the 2539 patients, 395 (16%) met the high-risk criteria. A DTBT ≤90min was achieved in 43% of HR-STEMI patients and in 55% of LR-STEMI patients. Patients in the HR-STEMI compared to LR-STEMI cohort had higher in-hospital (31% vs. 1%, p<0.01) and long-term mortality (37% vs. 7%, p<0.01). A DTBT ≤90min was associated with significant improvements in short- and long-term mortality in both groups. A DTBT ≤90min was an independent multivariate predictor of long-term survival in LR-STEMI (hazard ratio [HR] 0.5, 95% confidence interval [CI] 0.3-0.9, p=0.02) but not in HR-STEMI (HR 0.7, 95% CI 0.5-1.1, p=0.11). CONCLUSION: A DTBT ≤90min was associated with improved short- and long-term outcomes in high- and low-risk STEMI patients. However, it was only an independent predictor of long-term survival in LR-STEMI patients.
DOI: 10.1016/j.ijcard.2016.09.003
Journal: International Journal of Cardiology
PubMed URL:
Type: Journal Article
Subjects: Cardiogenic shock
Out-of-hospital cardiac arrest
Percutaneous coronary intervention
Risk assessment
Appears in Collections:Journal articles

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