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Title: Performance on the Cogstate Brief Battery Is related to amyloid levels and hippocampal volume in very mild dementia
Austin Authors: Lim, Yen Ying;Villemagne, Victor L ;Laws, Simon M;Pietrzak, Robert H;Ames, David;Fowler, Christopher J;Rainey-Smith, Stephanie R;Snyder, Peter J;Bourgeat, Pierrick;Martins, Ralph N;Salvado, Olivier;Rowe, Christopher C ;Masters, Colin L ;Maruff, Paul;AIBL Research Group
Affiliation: The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, Western Australia, Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia
Co-operative Research Centre for Mental Health, Carlton, Victoria, Australia
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, The University of Melbourne, Kew, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Department of Neurology, Alpert Medical School of Brown University, Providence, RI, USA
Commonwealth Scientific Industrial Research Organization (CSIRO) Preventative Health National Research Flagship, Australian e-Health Research Centre-BiaMedIA, Brisbane, Queensland, Australia
CogState Ltd., Melbourne, Victoria, Australi
Issue Date: Nov-2016 2016-09-01
Publication information: Journal of Molecular Neuroscience 2016; 60(3): 362-370
Abstract: In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. Participants were characterized according to their status on the Clinical Dementia Rating (CDR) scale. A total of 308 individuals who were CDR 0 and had low cerebral Aβ levels (Aβ-), 32 individuals who were Aβ- and CDR 0.5, and 43 individuals who were Aβ+ and CDR 0.5 were included in this study. Participants completed the CogState brief battery at baseline, and at 18-, 36-, 54- and 72-month follow-up. Linear mixed model analyses indicated that relative to the Aβ- CDR 0 group, the Aβ+ CDR 0.5 group showed increased rates of memory decline and hippocampal volume loss. However, compared to the Aβ- CDR 0 group, the Aβ- CDR 0.5 group showed no changes in cognitive function or hippocampal volume over 72 months. The results of this study confirm that in individuals with very mild dementia, who also have biomarker confirmation of Aβ+, changes in cognitive function manifest primarily as deterioration in memory processing, and this is associated with hippocampal volume loss. Conversely, the absence of any cognitive decline or loss in hippocampal volume in individuals with very mild dementia but who are Aβ- suggests that some other non-AD disease process may underlie any static impairment in cognitive function.
DOI: 10.1007/s12031-016-0822-8
ORCID: 0000-0002-2605-4766
PubMed URL:
Type: Journal Article
Subjects: Alzheimer’s disease
Hippocampal volume
Mild dementia
Appears in Collections:Journal articles

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