Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16299
Title: Image guidance and stabilization for stereotactic ablative body radiation therapy (SABR) treatment of primary kidney cancer
Austin Authors: Pham, Daniel;Kron, Tomas;Bressel, Mathias;Foroudi, Farshad ;Hardcastle, Nicholas;Schneider, Michal;Soteriou, Sally;Innes, Jayson;Siva, Shankar
Affiliation: Department of Radiation Therapy Services, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Medical Imaging and Radiation Sciences, Monash University, Melbourne, Victoria, Australia
Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia
Department of Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Department of Radiation Oncology, Olivia Newton-John Cancer Centre/Austin Health, Heidelberg, Victoria, Australia
Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Issue Date: Nov-2015
metadata.dc.date: 2015-08-20
Publication information: Practical Radiation Oncology 2015; 5(6): e597-e605
Abstract: PURPOSE: Stereotactic ablative body radiation therapy for primary kidney cancer treatment relies on motion management that can quantify both the trajectory of kidney motion and stabilize the patient. A prospective ethics-approved clinical trial of stereotactic treatment to primary kidney targets was conducted at our institution. Our aim was to report on specific kidney tumor motion and the inter- and intrafraction motion as seen on treatment. METHODS AND MATERIALS: Patients with tumor size <5 cm received a dose of 26 Gy in 1 fraction and those with tumor size ≥5 cm received 42 Gy in 3 fractions. All patients underwent a 4-dimensional computed tomography planning scan, immobilized in a dual-vacuum system. A conventional linear accelerator cone beam computed tomography scan was used for pre-, mid-, and posttreatment imaging to verify target position. RESULTS: Between July 2012 and October 2014, 33 targets from 32 consecutive patients (24 males/8 females) were treated. Seventeen targets were prescribed 26 Gy/1 fraction and the remaining 16 targets received 42 Gy/3 fractions. Kidney motion at each of the poles was not affected by the presence of tumor (P = .875), nor was the motion statistically different from the corresponding contralateral kidney pole (P = .909). The mean 3-dimensional displacement of the target at mid- and posttreatment was 1.3 mm (standard deviation ± 1.6) and 1.0 mm (standard deviation ± 1.3), respectively. The maximum displacement in any direction for 95% of the fractions at mid- and posttreatment was ≤3 mm. CONCLUSION: In summary, stereotactic ablative body radiation therapy of primary kidney targets can be accurately delivered on a conventional linear accelerator with protocol that has minimal intrafractional target motion.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16299
DOI: 10.1016/j.prro.2015.08.002
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/26547828
Type: Journal Article
Subjects: Kidney Neoplasms
Movement
Radiosurgery
Respiratory-Gated Imaging Techniques
Appears in Collections:Journal articles

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