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Title: Sepsis-Induced acute kidney injury
Austin Authors: Mårtensson, Johan;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Department of Physiology and Pharmacology, Section of Anaesthesia and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden
Department of Epidemiology and Preventive Medicine, Australian and New Zealand Intensive Care Research Centre, School of Preventive Medicine and Public Health, Monash University, Melbourne, Victoria, Australia
Issue Date: 15-Jul-2015
Date: 2015-10
Publication information: Critical Care Clinics 2015; 31(4): 649-660
Abstract: Acute kidney injury (AKI) is a serious yet potentially reversible complication of sepsis. Several molecular mechanisms involved in the development of septic AKI have been identified. These mechanisms may be important targets in the development of future therapies. This review highlights the role of the innate immune response to sepsis and its downstream effects on kidney structure and function with special reference to the adaptive cellular response and glomerular hemodynamic changes. In addition, current evidence surrounding the management of patients with septic AKI is summarized. Finally, potential novel therapies for septic AKI are presented.
DOI: 10.1016/j.ccc.2015.06.003
Journal: Critical Care Clinics
PubMed URL:
Type: Journal Article
Subjects: Acute kidney injury
Renal replacement therapy
Appears in Collections:Journal articles

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