Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16274
Title: The contribution of geometry to the human connectome
Austin Authors: Roberts, James A;Perry, Alistair;Lord, Anton R;Roberts, Gloria;Mitchell, Philip B;Smith, Robert E;Calamante, Fernando;Breakspear, Michael
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Systems Neuroscience Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia
Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia
Leibniz Institute for Neurobiology, Magdeburg, Germany
Black Dog Institute, Prince of Wales Hospital, Hospital Road, Randwick, NSW, Australia
The Florey Institute of Neuroscience and Mental Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health and Northern Health, University of Melbourne, Victoria, Australia
Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Metro North Mental Health Service, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia
Issue Date: 1-Jan-2016
metadata.dc.date: 2015-09-11
Publication information: NeuroImage 2016; 124(A): 379-393
Abstract: The human connectome is a topologically complex, spatially embedded network. While its topological properties have been richly characterized, the constraints imposed by its spatial embedding are poorly understood. By applying a novel resampling method to tractography data, we show that the brain's spatial embedding makes a major, but not definitive, contribution to the topology of the human connectome. We first identify where the brain's structural hubs would likely be located if geometry was the sole determinant of brain topology. Empirical networks show a widespread shift away from this geometric center toward more peripheral interconnected skeletons in each hemisphere, with discrete clusters around the anterior insula, and the anterior and posterior midline regions of the cortex. A relatively small number of strong inter-hemispheric connections assimilate these intra-hemispheric structures into a rich club, whose connections are locally more clustered but globally longer than predicted by geometry. We also quantify the extent to which the segregation, integration, and modularity of the human brain are passively inherited from its geometry. These analyses reveal novel insights into the influence of spatial geometry on the human connectome, highlighting specific topological features that likely confer functional advantages but carry an additional metabolic cost.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16274
DOI: 10.1016/j.neuroimage.2015.09.009
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/26364864
Type: Journal Article
Subjects: Brain
Connectome
Appears in Collections:Journal articles

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