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Title: Associations of neighborhood environment with brain imaging outcomes in the Australian Imaging, Biomarkers and Lifestyle cohort
Austin Authors: Cerin, Ester;Rainey-Smith, Stephanie R;Ames, David;Lautenschlager, Nicola T;Macaulay, S Lance;Fowler, Christopher J;Robertson, Joanne S;Rowe, Christopher C ;Maruff, Paul;Martins, Ralph N;Masters, Colin L ;Ellis, Kathryn A
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Institute for Health and Ageing, Australian Catholic University, Melbourne, Victoria, Australia
School of Public Health, The University of Hong Kong, Hong Kong, China
School of Exercise and Nutrition Sciences, Deakin University, Burwood, Victoria, Australia
Sir James McCusker Alzheimer's Disease Research Unit (Hollywood Private Hospital), Perth, Western Australia, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical Sciences, Edith Cowan University, Perth, Western Australia, Australia
Academic Unit for Psychiatry of Old Age, Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
CSIRO Food and Nutrition, Parkville, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
Cogstate Ltd., Melbourne, Victoria, Australia
Issue Date: Apr-2017
Date: 2016-08-19
Publication information: Alzheimer's & Dementia 2017; 13(4): 388-398
Abstract: INTRODUCTION: "Walkable" neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. METHODS: We objectively assessed neighborhood walkability for participants (n = 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid β burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE ε4 status, and the extent to which associations were explained by physical activity. RESULTS: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE ε4 carriers showed slower worsening of outcomes if living in walkable neighborhoods. DISCUSSION: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE ε4 carriers) minimally attributable to physical activity.
DOI: 10.1016/j.jalz.2016.06.2364
ORCID: 0000-0003-3910-2453
Journal: Alzheimer's & Dementia
PubMed URL:
Type: Journal Article
Subjects: Amyloid beta depositions
Apolipoprotein E genotype
Brain volumetric measures
Community dwellers
Enriched environment
Place of residence
Appears in Collections:Journal articles

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