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Title: Suspected acute hemolytic transfusion reaction mediated by anti-Di(a)
Austin Authors: Bennett, A ;Boyapati, RK;Hong, Frank S
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Haematology Department, Monash Medical Centre, Clayton, Victoria, Australia
Department of Gastroenterology, Western General Hospital, Edinburgh, Scotland
Austin Pathology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 2015 2015
Publication information: Immunohematology 2015; 31(4): 163-165
Abstract: Anti-Di(a) can mediate hemolytic disease of the fetus and newborn, but it is unclear if it can cause hemolytic transfusion reactions (HTRs). To date, there has only been one report of a possible immediate HTR attributed to anti-Di(a). Our case report details an immediate HTR due to anti-Di(a) in a patient with pre-existing liver failure. This reaction triggered multi-organ failure, and the patient subsequently died. This case also highlights the importance of considering HTRs even when routine antibody screening has been unremarkable, particularly when electronic crossmatch is used, because of the potential for an alloantibody against a low-prevalence antigen.
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Type: Journal Article
Subjects: Rho(D) Immune Globulin
Transfusion Reaction
Appears in Collections:Journal articles

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