Busulfan is effective second-line therapy for older patients with Philadelphia-negative myeloproliferative neoplasms intolerant of or unresponsive to hydroxyurea

2017-01

Douglas, Genevieve

Harrison, Claire

Forsyth, Cecily J

Bennett, Michael R

Stevenson, William

Hounsell, John

Ratnasingam, Sumita

Ritchie, David

Ross, David M

Grigg, Andrew P

Philadelphia-negative myeloproliferative neoplasms

Busulfan

Hydroxyurea

Journal Article

10.1080/10428194.2016.1187269

Hydroxyurea (Hu) is widely used as first-line cytoreductive therapy for patients with high-risk Philadelphia-negative myeloproliferative neoplasms (Ph-neg MPN), but a small proportion of patients have refractory disease or experience adverse effects. Studies have demonstrated busulfan (Bu) to be an active first-line agent, but data on its role as second-line or later therapy are minimal. To evaluate its efficacy and safety in this context, we undertook a multicenter audit of Ph-neg MPN patients who had received Bu as therapy for Hu intolerance or failure. Of 51 patients identified, 38 (75%) achieved either complete or partial hematological response following at least one Bu cycle. Bu was generally well tolerated, with only 21/135 (15%) cycles complicated by adverse effects, predominantly cytopenia; only 6% of cycles were ceased due to treatment complications. Bu is an effective and well-tolerated agent in patients with Ph-neg MPN in the setting of Hu intolerance or unresponsiveness.

link

Leukemia & Lymphoma 2017; 58(1): 89-95

Leukemia & Lymphoma