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Title: Magnesium status and magnesium therapy in critically ill patients: A systematic review
Austin Authors: Fairley, Jessica;Glassford, Neil J;Zhang, Ling;Bellomo, Rinaldo 
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Alfred Hospital, Prahran, Victoria, Australia
Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Prahran, Victoria, Australia
Department of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
Issue Date: Dec-2015
Date: 2015-07-31
Publication information: Journal of Critical Care 2015; 30(6): 1349-1358
Abstract: PURPOSE: Magnesium is frequently measured and administered in general intensive care unit patients. However, magnesium status, its association with outcomes, and therapeutic utility in such patients are unclear. We performed a systematic review of the relevant literature to define current knowledge in this field. MATERIALS AND METHODS: We searched MEDLINE, CENTRAL, and EMBASE from 1975 to July 2014 for adult English language articles excluding obstetric, non-intensive care unit based, and specific population (poisoning, cardiothoracic, and neurosurgery) studies. We identified articles on magnesium measurement, associations, and therapy. We calculated pooled effect estimates from reported adjusted risk estimates. RESULTS: We identified 34 relevant studies. Total serum total magnesium was the most commonly measure of magnesium status. Risk of mortality was significantly increased with hypomagnesemia (odds ratio, 1.85; 95% confidence interval, 1.31-2.60). No consistent associations existed between magnesemia or magnesium administration and any other outcomes. CONCLUSIONS: Total serum magnesium levels are generally used to estimate magnesium status in critical illness. Hypomagnesemia appears associated with greater risk of mortality, but the efficacy of magnesium administration is open to challenge.
DOI: 10.1016/j.jcrc.2015.07.029
Journal: Journal of Critical Care
PubMed URL:
Type: Journal Article
Subjects: Arrhythmia
Critical illness
Electrolyte disturbance
Intensive care
Magnesium therapy
Type of Clinical Study or Trial: Systematic Reviews
Appears in Collections:Journal articles

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