Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16141
Title: Synthesis of Oxorhenium(V) and Oxotechnetium(V) complexes that bind to Amyloid-? plaques
Austin Authors: Hayne, David J;White, Jonathan M;McLean, Catriona A;Villemagne, Victor L ;Barnham, Kevin J;Donnelly, Paul S
Affiliation: The Alfred Hospital, Melbourne, Victoria, Australia
Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Heidelberg, Victoria, Australia
School of Chemistry,The University of Melbourne, Melbourne, Victoria, Australia
Bio21 Institute, The University of Melbourne, Melbourne, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia
Issue Date: 15-Aug-2016
metadata.dc.date: 2016-08-15
Publication information: Inorganic Chemistry 2016; 55(16): 7944-7953
Abstract: Alzheimer's disease is characterized by the presence of amyloid plaques in the brain. The primary constituents of the plaques are aggregated forms of the amyloid-? (A?) peptide. With the goal of preparing technetium-99(m) complexes that bind to A? plaques with the potential to be diagnostic imaging agents for Alzheimer's disease, new tetradentate ligands capable of forming neutral and lipophilic complexes with oxotechentium(V) and oxorhenium(V) were prepared. Nonradioactive isotopes of technetium are not available so rhenium was used as a surrogate for exploratory chemistry. Two planar tetradentate N3O ligands were prepared that form charge-neutral complexes with oxorhenium(v) as well as a ligand featuring a styrylpyridyl functional group designed to bind to A? plaques. All three ligands formed complexes with oxorhenium(V), and each complex was characterized by NMR spectroscopy, mass spectrometry, and X-ray crystallography. The oxorhenium(V) complex with a styrylpyridyl functional group binds to A? plaques present in post-mortem human brain tissue. The chemistry was extrapolated to technetium-99(m) at the tracer level for two of the ligands. The resulting oxotechnetium(V) complexes were sufficiently lipophilic and charge-neutral to suggest that they have the potential to cross the blood-brain barrier but exhibited modest stability with respect to exchange with histidine. The chemistry presented here identifies a strategy to integrate styrylpyridyl functional groups into tetradentate ligands capable of forming complexes with [M?O](3+) cores (M = Re or Tc).
URI: http://ahro.austin.org.au/austinjspui/handle/1/16141
DOI: 10.1021/acs.inorgchem.6b00972
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27459001
Type: Journal Article
Appears in Collections:Journal articles

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