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Title: | Polymicrogyric cortex may predispose to seizures via abnormal network topology: an fMRI connectomics study | Austin Authors: | Sethi, Moksh ;Pedersen, Mangor;Jackson, Graeme D | Affiliation: | Austin Health, Heidelberg, Victoria, Australia The Florey Institute of Neuroscience and Mental Health, Austin Health, Heidelberg, Victoria, Australia Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia Department of Neurology, Austin Health, Heidelberg, Victoria, Australia |
Issue Date: | Mar-2016 | Date: | 2016-01-14 | Publication information: | Epilepsia 2016; 57(3): e64-68 | Abstract: | Polymicrogyria is a significant malformation of cortical development with a high incidence of epilepsy and cognitive deficits. Graph theoretic analysis is a useful approach to studying network organization in brain disorders. In this study, we used task-free functional magnetic resonance imaging (fMRI) data from four patients with polymicrogyria and refractory epilepsy. Gray matter masks from structural MRI data were parcellated into 1,024 network nodes. Functional “connectomes” were obtained based on fMRI time series between the parcellated network nodes; network analysis was conducted using clustering coefficient, path length, node degree, and participation coefficient. These graph metrics were compared between nodes within polymicrogyric cortex and normal brain tissue in contralateral homologous cortical regions. Polymicrogyric nodes showed significantly increased clustering coefficient and characteristic path length. This is the first study using functional connectivity analysis in polymicrogyria—our results indicate a shift toward a regular network topology in polymicrogyric nodes. Regularized network topology has been demonstrated previously in patients with focal epilepsy and during focal seizures. Thus, we postulate that these network alterations predispose to seizures and may be relevant to cognitive deficits in patients with polymicrogyria. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/16137 | DOI: | 10.1111/epi.13304 | Journal: | Epilepsia | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/26763051 | Type: | Journal Article | Subjects: | Cortical malformations Focal epilepsy Graph theory Polymicrogyria Resting state functional connectivity |
Appears in Collections: | Journal articles |
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