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Title: Update on Mucin-1 immunotherapy in cancer: a clinical perspective
Austin Authors: Rivalland, Gareth;Loveland, Bruce E;Mitchell, Paul L R 
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer and Wellness Centre, Austin Health, Heidelberg, Victoria, Australia
Burnet Institute, Centre for Biomedical Research, Melbourne, Victoria, Australia
Issue Date: 2015 2015-10-09
Publication information: Expert Opinion on Biological Therapy 2015; 15(12): 1773-1787
Abstract: INTRODUCTION: Mucin 1 (MUC1) is particularly well suited as a cancer immunotherapy target due to the elevated protein expression and aberrant forms associated with malignancy. A variety of therapeutic strategies have been explored, including antibodies intended to induce cancer cell destruction, and vaccinations with peptides, tumor extracts, and gene expression systems. AREAS COVERED: MUC1 immunotherapeutic strategies have included vaccination with peptide sequences, glycan molecules, viruses, and dendritic cells, monoclonal antibodies and monoclonal antibody conjugates. Here we review the relevant clinical trials in each field of immunotherapy with particular focus on large and recently published trials. EXPERT OPINION: Long clinical experience in the trial setting has reduced concerns of immunotherapy associated toxicities and inappropriate immune responses, with the main limitation (common to many experimental approaches) being a lack of clinical efficacy. However, there have been sufficient treatment-associated responses to justify continued pursuit of MUC1 targeted immunotherapies. The focus now should be on application to the relevant cancers under appropriate circumstances and combination with the emerging non-specific immunotherapy approaches such as the PD-1 pathway inhibitors.
DOI: 10.1517/14712598.2015.1088519
Journal: Expert Opinion on Biological Therapy
PubMed URL:
Type: Journal Article
Subjects: Mucin 1
Cancer vaccines
Clinical trials
Dendritic cells
Monoclonal antibodies
Viral vectors
Appears in Collections:Journal articles

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