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Title: Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment
Austin Authors: Buckley, Rachel F;Saling, Michael;Ellis, Kathryn A;Rowe, Christopher C ;Maruff, Paul;Macaulay, S Lance;Martins, Ralph N;Masters, Colin L ;Savage, Greg;Rainey-Smith, Stephanie R;Rembach, Alan;Ames, David
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Melbourne School of Psychological Sciences, University of Melbourne, Parkville, Victoria, Australia
Florey Institutes of Neuroscience and Mental Health, Melbourne, Victoria, Australia
National Ageing Research Institute, Melbourne, Victoria, Australia
The Academic Unit for Psychiatry of Old Age, St Vincent's Health, Melbourne, Victoria, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
The Department of Medicine, Austin Health, Heidelberg, Victoria, Australia
Cogstate Ltd., Melbourne, Victoria, Australia
Commonwealth Scientific Industrial Research Organization Food and Nutrition Flagship, Melbourne, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Perth, Western Australia, Australia
School of Psychiatry and Clinical Neurosciences and West Australian Centre for Health and Ageing, University of Western Australia, Perth, Western Australia, Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia
School of Psychiatry and Clinical Neurosciences, University of Western Australia, Sydney, New South Wales, Australia
Issue Date: Nov-2015
Date: 2015-10-08
Publication information: Age and Ageing 2015; 44(6): 1012-1019
Abstract: BACKGROUND: Information provided by an informant about a patient with cognitive change is an essential component of clinical history taking. How an informant's report relates to the patient's phenomenological experience of memory loss is yet to be understood. The aim was to examine patterns of relationships between self and informant reports from a phenomenological perspective. METHODS: Forty-three healthy non-memory complainers (HC-NMC), 37 healthy subjective memory complainers (HC-SMC) and 43 individuals with mild cognitive impairment (MCI) were administered a semi-structured interview, which measured their concerns of frequency of memory lapses and impact on mood. Informants responded to questionnaires. RESULTS: Self-reported concerns of increasing frequency and impacted mood related to informant concerns in HC-SMCs. MCI with lower informant concern showed a similar pattern to HC-SMCs on complaints of increasing frequency. In those with higher informant concern, self-reports markedly separated from informant concern. The MCI group with greater informant concern performed comparatively poor on verbal and non-verbal memory measures. CONCLUSIONS: Our results suggest that the association between self-reported and informant memory concerns is moderated by MCI severity. Self and informant reports of increasing memory lapse frequency aligned in HC-SMC and MCIs with low informant concern, suggesting a similar dyadic experience of memory change. In MCIs with greater informant concern, the pattern changed exposing a changing insight with advancing memory impairment. These individuals are potentially reflecting a 'forgetting that they forget' phenomenon in elements of their concern.
DOI: 10.1093/ageing/afv136
ORCID: 0000-0002-5356-5537
Journal: Age and Ageing
PubMed URL:
Type: Journal Article
Subjects: Alzheimer's disease
Mild cognitive impairment
Older people
Subjective memory complaints
Appears in Collections:Journal articles

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