Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16117
Title: A randomised controlled trial of peri-operative lidocaine infusions for open radical prostatectomy
Austin Authors: Weinberg, Laurence ;Rachbuch, C;Ting, S;Howard, W;Yeomans, M;Gordon, I;McNicol, L;James, K;Story, David A ;Christophi, Christopher 
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Anaesthesia, Peri-operative and Pain Medicine, University of Melbourne, Melbourne, Victoria, Australia
Department of Anaesthesia, Eastern Health, Box Hill, Victoria, Australia
Department of Anaesthesia, Monash Health, Clayton, Victoria, Australia
Acute Pain Service, Austin Health, Heidelberg, Victoria, Australia
Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia
Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia
Issue Date: Apr-2016
metadata.dc.date: 2016-01-08
Publication information: Anaesthesia 2016; 71(4): 405-410
Abstract: We allocated 76 men scheduled for radical retropubic prostatectomy to peri-operative lidocaine 2% or saline 0.9%: a pre-operative 0.075 ml.kg(-1) intravenous bolus; an intra-operative intravenous infusion at 0.075 ml.kg(-1) .h(-1) ; and 24 hours' postoperative subcutaneous infusion at 0.075 ml.kg(-1) .h(-1) . Lidocaine reduced the postoperative hospital stay by a mean (95% CI) of 1.3 (0.3-2.4) days, p = 0.017, from a mean (SD) of 4.6 (3.2) days with saline. Lidocaine reduced pain at rest during the first 24 postoperative hours by a mean (95% CI) of 1.8 (0.7-2.9) mm.h(-1) , p = 0.001. Lidocaine reduced 24-h morphine consumption by a mean (95% CI) of 13.9 (2.2-25.7) mg, p = 0.021, from a mean (SD) of 52.3 (26.9) mg with saline. There were no differences in other outcomes.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16117
DOI: 10.1111/anae.13368
ORCID: 0000-0001-7403-7680
0000-0002-6479-1310
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/26749026
Type: Journal Article
Subjects: Anesthetics
Lidocaine
Perioperative Care
Prostatectomy
Postoperative pain
Appears in Collections:Journal articles

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